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Titolo:
Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages
Autore:
Staege, H; Brauchlin, A; Schoedon, G; Schaffner, A;
Indirizzi:
Univ Zurich Hosp, Res Unit, Med Clin B, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
IMMUNOGENETICS
fascicolo: 2, volume: 53, anno: 2001,
pagine: 105 - 113
SICI:
0093-7711(200103)53:2<105:TNGFAL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-MONOCYTES; RESISTANCE; PROTEIN; INTERLEUKIN-4; OSTEOPONTIN; MODULATION; ACTIVATION; CELLS; CCR8; RNA;
Keywords:
human monocyte/macrophages; differential gene display; macrophage deactivation; Listeria monocytogenes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Schaffner, A Univ Zurich Hosp, Res Unit, Med Clin B, Raemistr 100, CH-8091Zurich, Switzerland Univ Zurich Hosp Raemistr 100 Zurich Switzerland CH-8091 and
Citazione:
H. Staege et al., "Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages", IMMUNOGENET, 53(2), 2001, pp. 105-113

Abstract

Deactivation of macrophage functions plays an important rule in human infectious and inflammatory diseases. In this study, differential-display RT-PCR was used to analyze the gene expression of human mononuclear phagocytes deactivated with interleukin (IL)-4, IL-10, and dexamethasone (DEX), in the absence and presence of infection with Listeria monocytogenes (Listeria). Two novel differentially expressed mRNA species were discovered: FIND (IL-Four INDuced) was upregulated with IL-4 but downregulated with DEX, and is predicted to code for an M-r 53,000 transmembrane protein. LIND (Listeria INDuced) was induced by Listeria infection, and is predicted to code for an M-r 39,000 nuclear or cytoplasmic protein containing three coiled-coil domains. In addition, we report several novel effects of deactivators and infection on the expression of known genes: (1) IL-C caused pronounced upregulation of ABCG2, coding for an ATP-binding cassette transporter highly expressedin the placenta, which mediates multidrug, resistance of cancer cells, butis otherwise of unknown function; (2) both DEX and IL-4 downregulated osteopontin, an important factor of host resistance against intracellular infections; (3) inhibition of the CC-chemokine I-309 mRNA expression by all three deactivators in the presence of Listeria infection, and (3) upregulation by Lister-in infection of the interferon-stimulated gene ISG20 of unknown function, whose product localizes with nuclear dots/ PML bodies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:31:51