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Titolo:
Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT
Autore:
Bunnell, SC; Kapoor, V; Trible, RP; Zhang, WG; Samelson, LE;
Indirizzi:
NCI, Div Basic Sci, Cellular & Mol Biol Lab, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Cellular & Mol Biol Lab, Bethesda, MD 20892 USA Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Med Ctr, Dept Immunol, Durham, NC 27710 USA
Titolo Testata:
IMMUNITY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 315 - 329
SICI:
1074-7613(200103)14:3<315:DAPDTC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
WISKOTT-ALDRICH-SYNDROME; MICROTUBULE-ORGANIZING CENTER; CYTOSKELETAL REORGANIZATION; PHOSPHOLIPASE C-GAMMA-1; IMMUNOLOGICAL SYNAPSE; TYROSINE KINASES; SYNDROME PROTEIN; B-CELLS; ACTIVATION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Samelson, LE NCI, Div Basic Sci, Cellular & Mol Biol Lab, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 l Biol Lab, Bethesda, MD 20892 USA
Citazione:
S.C. Bunnell et al., "Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT", IMMUNITY, 14(3), 2001, pp. 315-329

Abstract

T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips coated with antibodies to the T cell receptor (TCR). Using these images, we were able to quantitate the morphological responses of individual cells over time. Here, we show that TCR engagement triggers the formation and expansion of contactsbounded by continuously remodeled actin-rich rings, These processes are associated with the extension of lamellipodia and require actin polymerization, tyrosine kinase activation, cytoplasmic calcium increases, and LAT, an important hematopoietic adaptor. In addition, the maintenance of the resulting contact requires sustained calcium influxes, an intact microtubule cytoskeleton, and functional LAT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:49:30