Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IKK beta is essential for protecting T cells from TNF alpha-induced apoptosis
Autore:
Senftleben, U; Li, ZW; Baud, V; Karin, M;
Indirizzi:
Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct,La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ansduct,La Jolla, CA 92093 USA Univ Munich, Klinikum Grosshadern, Anesthesiol Clin, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 thesiol Clin, D-81377 Munich, Germany
Titolo Testata:
IMMUNITY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 217 - 230
SICI:
1074-7613(200103)14:3<217:IBIEFP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; MOUSE BONE-MARROW; IMMUNE-RESPONSES; DEFICIENT MICE; INCONTINENTIA PIGMENTI; EMBRYONIC LETHALITY; LIVER DEGENERATION; KINASE COMPLEX; ACTIVATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Karin, M Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct,La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093a Jolla, CA 92093 USA
Citazione:
U. Senftleben et al., "IKK beta is essential for protecting T cells from TNF alpha-induced apoptosis", IMMUNITY, 14(3), 2001, pp. 217-230

Abstract

Transcription factor NF-KB, whose activation depends on the IKK beta catalytic subunit of the I kappaB kinase, was assigned with both anti- and proapoptotic functions in T lymphocytes. To critically evaluate these functions,we transferred Ikk beta (-/-) or wild-type (wt) fetal liver (FL) stem cells into lethally irradiated mice. Ikk beta (-/-) radiation chimeras show thymic rudiments, aberrant lymphoid organs, and absence of T cells. T lymphopoiesis is rescued when Ikk beta (-/-) stem cells are cotransferred with wt bone marrow, suggesting that IKK beta may mediate its lymphopoietic functionvia extrinsic factors. However, almost normal development of Ikk beta (-/-) T cells is observed upon removal of type 1 TNF alpha receptor, indicatingthat TNF alpha signaling accounts for the absence of Ikk beta (-/-) T cells. Indeed, Ikk beta (-/-) radiation chimeras exibit elevated circulating TNF alpha, and Ikk beta (-/-) thymocytes display increased TNF alpha sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:01:35