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Titolo:
ANALYSIS OF TIE RECEPTOR TYROSINE KINASE IN HEMATOPOIETIC PROGENITOR AND LEUKEMIA-CELLS
Autore:
KUKK E; WARTIOVAARA U; GUNJI Y; KAUKONEN J; BUHRING HJ; RAPPOLD I; MATIKAINEN MT; VIHKO P; PARTANEN J; PALOTIE A; ALITALO K; ALITALO R;
Indirizzi:
UNIV HELSINKI,HAARTMAN INST,TRANSPLANTAT LAB,MOL CANC BIOL LAB,PL21 FIN-00014 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT CLIN CHEM FIN-00014 HELSINKI FINLAND UNIV HELSINKI,CENT HOSP,DEPT INTERNAL MED,DIV CLIN HAEMATOL FIN-00014HELSINKI FINLAND UNIV TUBINGEN,MED KLIN,ABT 2 D-7400 TUBINGEN GERMANY UNIV TURKU,CTR BIOTECHNOL TURKU FINLAND OULU UNIV,DEPT CLIN CHEM OULU FINLAND
Titolo Testata:
British Journal of Haematology
fascicolo: 1, volume: 98, anno: 1997,
pagine: 195 - 203
SICI:
0007-1048(1997)98:1<195:AOTRTK>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELLS; GROWTH-FACTOR; MOUSE TIE; EXPRESSION; GENE; LINE; TEK; ESTABLISHMENT; ERYTHROPOIETIN; HYBRIDIZATION;
Keywords:
TIE; ANGIOPOIETIN-1; CD34(+) CELLS; HEMATOPOIESIS; LEUKEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E. Kukk et al., "ANALYSIS OF TIE RECEPTOR TYROSINE KINASE IN HEMATOPOIETIC PROGENITOR AND LEUKEMIA-CELLS", British Journal of Haematology, 98(1), 1997, pp. 195-203

Abstract

We generated a panel of monoclonal antibodies against the extracellular domain of the Tie receptor tyrosine kinase and studied its expression in human haemopoietic and tumour cell lines and in samples from leukaemia patients, Most of the erythroblastic/megakaryoblastic (6/8), 2/7 myeloid and 3/6 B-lymphoblastic leukaemia cell lines were Tie-positive, The erythroblastic/megakaryoblastic leukaemia cell lines also expressed the related Tie-2/Tek gene and, surprisingly, its recently cloned ligand gene angiopoietin-1, which was located in chromosome 8q23.1. In addition, 16% of freshly isolated leukaemia samples were Tie positive. Peripheral blood mononuclear cells were Tie negative, but a few Tie positive cells were found in immunoperoxidase staining of mobilized peripheral blood stem cells. Long-term culture of isolated umbilical cord blood CD34(+)Tie(+) and CD34(+)Tie(-)cells indicated that the Tie() fraction contained a slightly higher frequency of cobblestone area forming cells (CAFC). Thus, Tie is expressed on haemopoietic progenitor cells and some leukaemic blasts. The coexpression of Tie-2 and angiopoietin-1 in megakaryoblastic leukaemia cell lines suggests the existence of an autocrine ligand/receptor signalling loop in these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:02:37