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Titolo:
High serum level of procollagen type III amino-terminal peptide contributes to the efficacy of spironolactone and angiotensin-converting enzyme inhibitor therapy on left ventricular hypertrophy in essential hypertensive patients
Autore:
Sato, A; Takane, H; Saruta, T;
Indirizzi:
Mito Red Cross Hosp, Dept Internal Med, Mito, Ibaraki 3100011, Japan Mito Red Cross Hosp Mito Ibaraki Japan 3100011 to, Ibaraki 3100011, Japan Keio Univ, Dept Internal Med, Tokyo, Japan Keio Univ Tokyo JapanKeio Univ, Dept Internal Med, Tokyo, Japan
Titolo Testata:
Hypertension research
fascicolo: 2, volume: 24, anno: 2001,
pagine: 99 - 104
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC FIBROSIS; MYOCARDIAL-INFARCTION; HEART-FAILURE; ALDOSTERONE; RAT; PREVENTION; TURNOVER; BLOCKADE; SALT;
Keywords:
mineralocorticoid receptor antagonist; angiotensin-converting enzyme inhibitor; essential hypertension; cardiac fibrosis; serum PIIINP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Sato, A Mito Red Cross Hosp, Dept Internal Med, 3-12-48 San Nomaru, Mito, Ibaraki 3100011, Japan Mito Red Cross Hosp 3-12-48 San Nomaru Mito Ibaraki Japan 3100011
Citazione:
A. Sato et al., "High serum level of procollagen type III amino-terminal peptide contributes to the efficacy of spironolactone and angiotensin-converting enzyme inhibitor therapy on left ventricular hypertrophy in essential hypertensive patients", HYPERTENS R, 24(2), 2001, pp. 99-104

Abstract

We recently demonstrated that spironolactone may have beneficial effects on left ventricular hypertrophy in selected patients with essential hypertension undergoing treatment with an angiotensin-converting enzyme (ACE) inhibitor. To clarify the possible mechanisms by which spironolactone improves cardiac hypertrophy, we investigated the change in serum procollagen type III amino-terminal peptide(PIIINP) in 11 patients with essential hypertensiontreated with spironolactone and an ACE inhibitor for 24 weeks. Both blood pressure and serum PIIINP levels were significantly decreased by treatment. There was a statistical significant correlation between the changes in LVMI and those in PIIINP, The reduction in PIIINP was significant in patients whose initial serum PIIINP levels were above the normal range. Before treatment, there were no statistically significant correlations between serum PIIINP levels and either LVMI, blood pressure, or plasma aldosterone concentration. Essential hypertensive patients matched in terms of duration of therapy, blood pressure and LVMI and treated with an ACE inhibitor alone showedno change in serum PIIINP levels. In conclusion, the results of the present study demonstrate that patients with essential hypertension and high serum levels of PIIINP are particularly responsive to MR blockade in terms of left ventricular hypertrophy, Moreover, these results suggest that spironolactone limits cardiac collagen turnover in such patients. Larger studies mayprovide definitive evidence for the involvement of aldosterone in left ventricular hypertrophy in patients with abnormally high PIIINP levels.

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Documento generato il 10/04/20 alle ore 02:38:30