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Titolo:
Increased reproductive success of MHC class II heterozygous males among free-ranging rhesus macaques
Autore:
Sauermann, U; Nurnberg, P; Bercovitch, FB; Berard, JD; Trefilov, A; Widdig, A; Kessler, M; Schmidtke, J; Krawczak, M;
Indirizzi:
Univ Wales Coll Med, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF14 4XN CF14 4XN, S Glam, Wales Deutsch Primatenzentrum, Arbeitsgrp Primatengenet, D-37077 Gottingen, Germany Deutsch Primatenzentrum Gottingen Germany D-37077 077 Gottingen, Germany Univ Klinikum Charite, Inst Med Genet, D-10098 Berlin, Germany Univ Klinikum Charite Berlin Germany D-10098 et, D-10098 Berlin, Germany Univ Puerto Rico, Caribbean Primate Res Ctr, Sabana Seca, PR 00952 USA Univ Puerto Rico Sabana Seca PR USA 00952 Ctr, Sabana Seca, PR 00952 USA Med Hsch Hannover, Inst Humangenet, D-30623 Hannover, Germany Med Hsch Hannover Hannover Germany D-30623 et, D-30623 Hannover, Germany
Titolo Testata:
HUMAN GENETICS
fascicolo: 3, volume: 108, anno: 2001,
pagine: 249 - 254
SICI:
0340-6717(200103)108:3<249:IRSOMC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; DQ-DRB HAPLOTYPE; MACACA-MULATTA; BALANCING SELECTION; LOCI; HLA; POPULATION; VIRUS; OVERDOMINANT; PATERNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Krawczak, M Univ Wales Coll Med, Inst Med Genet, Heath Pk, Cardiff CF14 4XN, S Glam, Wales Univ Wales Coll Med Heath Pk Cardiff S Glam Wales CF14 4XNles
Citazione:
U. Sauermann et al., "Increased reproductive success of MHC class II heterozygous males among free-ranging rhesus macaques", HUM GENET, 108(3), 2001, pp. 249-254

Abstract

Gene conversion and balancing selection have been invoked to explain the ubiquitous diversity of the antigen-presenting proteins encoded in the vertebrate major histocompatibility complex (MHC). In the present study, direct evidence for over-dominant selection promoting MHC diversity in primates isprovided by the observation that, in a large free-ranging population of rhesus macaques, males heterozygous at MHC class II locus Mamu-DQB1 sired significantly more offspring than homozygotes (the male-specific selection coefficient s equals 0.34). This heterozygote advantage appeared to be independent of the actual male Mamu-DQB1 genotype. No similar effect emerged for acaptive group of monkeys of similar genetic background but under veterinary care.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:37:37