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Titolo:
Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes
Autore:
Lazo, PA; Nadal, M; Ferrer, M; Area, E; Hernandez-Torres, J; Nabokina, SM; Mollinedo, F; Estivill, X;
Indirizzi:
Univ Salamanca, CSIC, Inst Biol Mol & Celular Canc, Ctr Invest Canc, Salamanca 37007, Spain Univ Salamanca Salamanca Spain 37007 Invest Canc, Salamanca 37007, Spain Hosp Duran & Reynals, Inst Rec Oncol, Ctr Genet Med & Mol, Barcelona 08907, Spain Hosp Duran & Reynals Barcelona Spain 08907 & Mol, Barcelona 08907, Spain CSIC, Ctr Nacl Biol Fundamental, Unidad Genet & Med Mol, Majadahonda 28220, Spain CSIC Majadahonda Spain 28220 d Genet & Med Mol, Majadahonda 28220, Spain Univ Valladolid, CSIC, Fac Med, Inst Mol Biol & Genet, E-47005 Valladolid,Spain Univ Valladolid Valladolid Spain E-47005 Genet, E-47005 Valladolid,Spain
Titolo Testata:
HUMAN GENETICS
fascicolo: 3, volume: 108, anno: 2001,
pagine: 211 - 215
SICI:
0340-6717(200103)108:3<211:GOCLAS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-MEMBRANE; HL-60 CELLS; SNAP-23; NEUTROPHILS; EXOCYTOSIS; MACHINERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Lazo, PA Univ Salamanca, CSIC, Inst Biol Mol & Celular Canc, Ctr Invest Canc, Campus Miguel Unamuno, Salamanca 37007, Spain Univ Salamanca Campus Miguel Unamuno Salamanca Spain 37007 Spain
Citazione:
P.A. Lazo et al., "Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes", HUM GENET, 108(3), 2001, pp. 211-215

Abstract

Synaptosome-associated protein-23 (SNAP23) is a component of the cellular mechanism required for specific membrane fusion and targetting of intracellular vesicles. We have cloned the full-length human cDNA and the SNAP23 gene. The SNAP23 gene has eight exons, with the initiation codon located in exon 2, and maps to the human chromosome 15q21-22 region. The human SNAP23 gene can generate two types of message, the full-length message (SNAP23A) anda shorter message (SNAP23B). The latter is the result of alternative splicing where exon 5 is joined to exon 7 and the skipping of exon 6; it thus lacks a region that is required for non-specific binding to plasma membranes. The two isoforms, expressed as fusion proteins with glutathione-S-transferase, interact in vitro with human syntaxin 6, thus retaining the specific protein interaction required for membrane fusion. Alterations in the SNAP23 gene might be involved in neurological and other diseases with defects in vesicle-membrane fusion processes that map to 15q15-21.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:30:56