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Titolo:
The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption
Autore:
Yoshimura, T; Yoshimura, M; Tabata, A; Yasue, H; Okamura, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Obstet & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan
Titolo Testata:
HUMAN GENETICS
fascicolo: 3, volume: 108, anno: 2001,
pagine: 181 - 183
SICI:
0340-6717(200103)108:3<181:TMGVOT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEIDEN MUTATION; PREGNANCY; HYPERTENSION; FREQUENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshimura, T Kumamoto Univ, Sch Med, Dept Obstet & Gynecol, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 umamoto 8608556, Japan
Citazione:
T. Yoshimura et al., "The missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption", HUM GENET, 108(3), 2001, pp. 181-183

Abstract

We recently identified a missense variant (Glu298Asp) that lies within exon 7 of the endothelial nitric oxide synthase (eNOS) gene, and that is associated with severe preeclampsia (proteinuric hypertension that develops as aconsequence of pregnancy). Maternal hypertension is the most consistently identified factor predisposing to placental abruption. Our objective, therefore, was to analyze the association between the Glu298Asp eNOS gene variant and placental abruption. The study participants included 35 patients withhistories of placental abruption and 170 control subjects. Screening for the Glu298Asp eNOS gene variant was carried out by analysis of polymerase chain reaction/restriction fragment length polymorphism. The analyses revealed that the frequency of the Glu298Asp variant (Glu298 Asp homozygotes and heterozygotes) was significantly (P<0.001) higher in the placental abruptiongroup (n=14; 40%) than in the control group (n=24; 14%). We conclude that the presence of the Glu298Asp eNOS gene variant could be a marker of increased risk of developing placental abruption.

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Documento generato il 25/11/20 alle ore 00:39:04