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Titolo:
Genetic imbalances in 26 cases of penile squamous cell carcinoma
Autore:
Alves, G; Heller, A; Fiedler, W; Campos, MM; Claussen, U; Ornellas, AA; Liehr, T;
Indirizzi:
Inst Nacl Canc, Lab Marcadores Celulares, Hematol Serv, Div Genet, BR-20230130 Rio De Janeiro, RJ, Brazil Inst Nacl Canc Rio De Janeiro RJ Brazil BR-20230130 BCJaneiro, RJ, Brazil Univ Jena, Inst Human Genet & Anthropol, Jena, Germany Univ Jena Jena Germany ena, Inst Human Genet & Anthropol, Jena, Germany Inst Nacl Canc, Div Expt Med, Rio De Janeiro, Brazil Inst Nacl Canc Rio De Janeiro Brazil v Expt Med, Rio De Janeiro, Brazil Inst Nacl Canc, Urol Serv, Rio De Janeiro, Brazil Inst Nacl Canc Rio De Janeiro Brazil Urol Serv, Rio De Janeiro, Brazil
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 31, anno: 2001,
pagine: 48 - 53
SICI:
1045-2257(200105)31:1<48:GII2CO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; DNA COPY NUMBER; CYTOGENETIC ANALYSIS; SOLID TUMORS; CHROMOSOMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Alves, G Inst Nacl Canc, Lab Marcadores Celulares, Hematol Serv, Div Genet, Pca Cruz Vermelha 23,7 Andar, BR-20230130 Rio De Janeiro, RJ, Brazil InstNacl Canc Pca Cruz Vermelha 23,7 Andar Rio De Janeiro RJ Brazil BR-20230130 BC
Citazione:
G. Alves et al., "Genetic imbalances in 26 cases of penile squamous cell carcinoma", GENE CHROM, 31(1), 2001, pp. 48-53

Abstract

To obtain more information on chromosomal changes in the up-to-now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed acomparative genomic hybridization study of 26 cases of this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected inother SCC types, such as oral and esophageal SCC, were noted. The most common copy number gains were found in 8q24, 16p11-12, 20q11-13, 22q, 19q13, and 5p15, and the most common deletions were detected in 13q21-22, 4q21-32, and along the X chromosome. Classifying the patients according to the number of CNAs showed a possible correlation with clinical outcome, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:16:23