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Titolo:
Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults
Autore:
Warr, T; Ward, S; Burrows, L; Harding, B; Wilkins, P; Harkness, W; Hayward, R; Darling, J; Thomas, D;
Indirizzi:
Univ Coll London, Natl Hosp Neurol & Neurosurg, Inst Neurol, Dept Neurosurg, London WC1N 3BG, England Univ Coll London London England WC1N 3BG osurg, London WC1N 3BG, England Great Ormond St Hosp Children NHS Trust, Dept Neuropathol, London WC1N 3JH, England Great Ormond St Hosp Children NHS Trust London England WC1N 3JH England Atkinson Morleys Hosp, Dept Neuropathol, London, England Atkinson Morleys Hosp London England Dept Neuropathol, London, England Great Ormond St Hosp Children NHS Trust, Dept Neurosurg, London, England Great Ormond St Hosp Children NHS Trust London England London, England
Titolo Testata:
GENES CHROMOSOMES & CANCER
fascicolo: 1, volume: 31, anno: 2001,
pagine: 15 - 22
SICI:
1045-2257(200105)31:1<15:IOEGLA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDIATRIC BRAIN-TUMORS; NERVOUS-SYSTEM TUMORS; GROWTH-FACTOR RECEPTOR; HUMAN GLIOMAS; CYTOGENETIC ANALYSIS; SUPPRESSOR GENE; GLIOBLASTOMA-MULTIFORME; COMMON DELETION; CHROMOSOME 19Q; DNA-SEQUENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Warr, T Univ Coll London, Natl Hosp Neurol & Neurosurg, Inst Neurol, Dept Neurosurg, Queen Sq, London WC1N 3BG, England Univ Coll London Queen Sq London England WC1N 3BG 1N 3BG, England
Citazione:
T. Warr et al., "Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults", GENE CHROM, 31(1), 2001, pp. 15-22

Abstract

Although astrocytomas are the most common central nervous system tumours in all age groups, there is substantial evidence that tumours arising in young patients (< 25 years of age) do not have the same genetic abnormalities that are characteristic of tumours in older patients. Furthermore, novel, consistent changes have not been identified in astrocytomas in children and young adults. We analysed 13 malignant astrocytomas from young patients using comparative genomic hybridisation. Regions of genomic imbalance were identified in 10 cases. The most common recurrent copy number aberrations wereloss of 16p (54% of cases), 17p (38%), 19p (38%), and 22 (38%) and gain on2q (38%), 12q (38%), 13 (38%), 4q (31%), 5q (31%), and 8q (31%). Seven regions of high copy number amplification were observed at 8q21-22 (three cases), 7q22-23 (two cases), and 1p21-22, 2q22, 12q13-pter, 12q15-21, and 13q11-14 tone case each). This study provides evidence of new characteristic chromosomal imbalances from which potential candidate genes involved in the development of malignant astrocytoma in children and young adults may be identified, <(c)> 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:08:53