Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Administration of subtumor regression dosage of TNF-alpha to mice with pre-existing parental tumors augments the vaccination effect of TNF gene-modified tumor through the induction of MHC class I molecule
Autore:
Lu, Y; Yamauchi, N; Koshita, Y; Fujiwara, H; Sato, Y; Fujii, S; Takahashi, M; Sato, T; Kato, J; Yamagishi, H; Niitsu, Y;
Indirizzi:
Sapporo Med Univ, Sch Med, Sect 4, Dept Internal Med,Chuo Ku, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ Sapporo Hokkaido Japan 0608543 , Hokkaido 0608543, Japan Kyoto Prefectural Univ, Sch Med, Dept Surg, Kyoto 606, Japan Kyoto Prefectural Univ Kyoto Japan 606 Med, Dept Surg, Kyoto 606, Japan Asari Hosp, Dept Internal Med, Otaru, Hokkaido, Japan Asari Hosp Otaru Hokkaido Japan ept Internal Med, Otaru, Hokkaido, Japan Kiyota Hosp, Dept Internal Med, Sapporo, Hokkaido, Japan Kiyota Hosp Sapporo Hokkaido Japan nternal Med, Sapporo, Hokkaido, Japan Sun Yat Sen Univ Med Sci, Ctr Canc, Dept Hematol Oncol, Guangzhou, PeoplesR China Sun Yat Sen Univ Med Sci Guangzhou Peoples R China zhou, PeoplesR China
Titolo Testata:
GENE THERAPY
fascicolo: 7, volume: 8, anno: 2001,
pagine: 499 - 507
SICI:
0969-7128(200104)8:7<499:AOSRDO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; INTERCELLULAR-ADHESION MOLECULE-1; HLA-CLASS-I; INFILTRATING LYMPHOCYTES; ANTIGEN EXPRESSION; ANTITUMOR-ACTIVITY; INTERFERON-GAMMA; CANCER-PATIENTS; PHASE-I; T-CELLS;
Keywords:
TNF; gene therapy; vaccination; MHC class I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Niitsu, Y Sapporo Med Univ, Sch Med, Sect 4, Dept Internal Med,Chuo Ku, South 1,West16, Sapporo, Hokkaido 0608543, Japan Sapporo Med Univ South 1,West 16 Sapporo Hokkaido Japan 0608543
Citazione:
Y. Lu et al., "Administration of subtumor regression dosage of TNF-alpha to mice with pre-existing parental tumors augments the vaccination effect of TNF gene-modified tumor through the induction of MHC class I molecule", GENE THER, 8(7), 2001, pp. 499-507

Abstract

One obstacle in treating pre-existing parental tumors by vaccination with cytokine gene-modified tumor cells is the impaired expression of immune-related molecules such as MHC class I. In this study, to enhance MHC class I expression on pre-inoculated parental tumors, low dose TNF (300 U, 500 U, 1000 U), that is, TNF at levels shown to cause neither tumor regression nor any severe adverse reaction, was systemically injected into parental tumors bearing mice before vaccination with TNF gene-modified Meth-A cells or B-16cells. Since the class I expression was confirmed to continue for at least24 h following administration of TNF, TNF was administered 6 h before vaccination. Complete regression of relatively large parental tumors (Ma) (8.0-10.0 mm in diameter) was observed in five of eight mice treated with 1000 UTNF. partial regression was observed in mice treated with 500 U, and a lesser yet significant regression was observed in mice treated with only 300 U. Contrarily. in the mice which had received vaccination without the TNF pretreatment no complete regression was observed. This effect was inhibited with the anti-class I antibody or anti-CD8 antibody. Growth of a reestablished, B16 tumor was significantly suppressed with a combination of TNF preadministration and vaccination of TNF gene-modified B16. These results indicate that preadministration of low-dose TNF may be promising for enhancing vaccination effects of TNF gene-modified tumor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:26:33