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Titolo:
ADHII in Aspergillus nidulans is induced by carbon starvation stress
Autore:
Jones, IG; Fairhurst, V; Sealy-Lewis, HM;
Indirizzi:
Univ Hull, Dept Biol Sci, Hull HU6 7RX, N Humberside, England Univ Hull Hull N Humberside England HU6 7RX U6 7RX, N Humberside, England
Titolo Testata:
FUNGAL GENETICS AND BIOLOGY
fascicolo: 1, volume: 32, anno: 2001,
pagine: 33 - 43
SICI:
1087-1845(200102)32:1<33:AIANII>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENICILLIN BIOSYNTHETIC GENE; ACETATE REGULATORY GENE; CATABOLITE REPRESSION; ETHANOL REGULON; BINDING-SITES; TRANSCRIPTIONAL ACTIVATOR; ALCOHOL DEHYDROGENASES; NEUROSPORA-CRASSA; CREA REPRESSOR; ACIA GENE;
Keywords:
Aspergillus nidulans; ADHII; starvation stress; creA; CreA-independent carbon catabolite repression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Sealy-Lewis, HM Univ Hull, Dept Biol Sci, Hull HU6 7RX, N Humberside, England Univ Hull Hull N Humberside England HU6 7RX side, England
Citazione:
I.G. Jones et al., "ADHII in Aspergillus nidulans is induced by carbon starvation stress", FUNGAL G B, 32(1), 2001, pp. 33-43

Abstract

in Aspergillus nidulans there are three NAD(+)-dependent alcohol dehydrogenases (ADHs) that are capable of utilizing ethanol as a substrate. ADHI is the physiological enzyme of ethanol catabolism and ADHIII is induced under conditions of anaerobiosis. The physiological role of ADHII (structural gene alcB) is unknown. We have measured beta -galactosidase in a transformant with an alcB::lacZ fusion and have shown that alcB is maximally expressed under conditions of carbon starvation. The behavior of the alcB::lacZ transformant suggests a hierarchy of repressing carbon sources characteristic of repression by the general carbon catabolite repressor protein, CreA, but ina creA(d)30 background the transformant shows only partial derepression ofP-galactosidase on 1% glucose compared to the creA(+) strain. Our results suggest that, in addition to carbon catabolite repression acting via CreA, a CreA-independent mechanism is involved in induction of alcB on carbon starvation. (C) 2001 Academic Press.

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Documento generato il 23/01/20 alle ore 06:21:48