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Titolo:
Effects of aging on the susceptibility to the toxic effects of cyclosporinA in rats. Changes in liver glutathione and antioxidant enzymes
Autore:
Palomero, J; Galan, AI; Munoz, ME; Tunon, MJ; Gonzalez-Gallego, J; Jimenez, R;
Indirizzi:
Univ Salamanca, Dept Fisiol & Farmacol, E-37007 Salamanca, Spain Univ Salamanca Salamanca Spain E-37007 armacol, E-37007 Salamanca, Spain Univ Leon, Dept Physiol, E-24071 Leon, Spain Univ Leon Leon Spain E-24071 niv Leon, Dept Physiol, E-24071 Leon, Spain
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 8, volume: 30, anno: 2001,
pagine: 836 - 845
SICI:
0891-5849(20010415)30:8<836:EOAOTS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LIPID-PEROXIDATION; A-INDUCED ALTERATIONS; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; FREE-RADICALS; BILIARY-SECRETION; RENAL MICROSOMES; SKELETAL-MUSCLE; DEFENSE; KIDNEY;
Keywords:
aging; antioxidant enzymes; cyclosporin A; free radicals; glutathione; hepatotoxicity; lipoperoxidation; liver; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Jimenez, R Univ Salamanca, Dept Fisiol & Farmacol, Edif Dept B-25,Campus MUnamuno, E-37007 Salamanca, Spain Univ Salamanca Edif Dept B-25,Campus M Unamuno Salamanca Spain E-37007
Citazione:
J. Palomero et al., "Effects of aging on the susceptibility to the toxic effects of cyclosporinA in rats. Changes in liver glutathione and antioxidant enzymes", FREE RAD B, 30(8), 2001, pp. 836-845

Abstract

Free radicals are involved in aging and cyclosporin A-induced toxicity. The age-related changes in the liver oxidative status of glutathione, lipid peroxidation, and the activity of the enzymatic antioxidant defense system, as well as the influence of aging on the susceptibility to the hepatotoxic effects of cyclosporin (CyA) were investigated in rats of different ages (1, 2, 4, and 24 months). The hepatic content of reduced glutathione (GSH) increased with aging, peaked at 4 months, and decreased in senescent rats. Bycontrast, glutathione disulfide (GSSG) and thiobarbituric acid-reactive substances (TBARS) concentrations and superoxide dismutase, catalase, and glutathione peroxidase activities were higher in the oldest than in the youngest rats. CyA treatment, besides inducing the well-known cholestatic syndrome, increased liver GSSG and TEARS contents and the GSSG/GSH molar ratio, and altered the nonenzymatic and enzymatic antioxidant defense systems. The CyA-induced cholestasis and hepatic depletion of GSH, and the increases in the GSSG/GSH ratio, and in GSSG and TEARS concentrations were higher in the older than the mature rats. Moreover, superoxide dismutase and catalase activities were found to be significantly decreased only in treated senescent rats. The higher CyA-induced oxidative stress, lipoperoxidation, and decreases in the antioxidant defense systems in the aged animals render them moresusceptible to the hepatotoxic effects of cyclosporin. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:08:24