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Titolo:
Disposition, accumulation and toxicity of iron fed as iron (II) sulfate oras sodium iron EDTA in rats
Autore:
Appel, MJ; Kuper, CF; Woutersen, RA;
Indirizzi:
TNO, Nutr & Food Res, Dept Gen Toxicol, NL-3700 AJ Zeist, Netherlands TNOZeist Netherlands NL-3700 AJ Toxicol, NL-3700 AJ Zeist, Netherlands
Titolo Testata:
FOOD AND CHEMICAL TOXICOLOGY
fascicolo: 3, volume: 39, anno: 2001,
pagine: 261 - 269
SICI:
0278-6915(200103)39:3<261:DAATOI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; OVERLOAD; LIVER; FORTIFICATION; MALONDIALDEHYDE; METABOLISM; ABSORPTION; SPLEEN; DIETS;
Keywords:
sodium iron EDTA; iron (II) sulfate; disposition; accumulation; toxicity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Woutersen, RA TNO, Nutr & Food Res, Dept Gen Toxicol, POB 360, NL-3700 AJ Zeist, Netherlands TNO POB 360 Zeist Netherlands NL-3700 AJ Zeist, Netherlands
Citazione:
M.J. Appel et al., "Disposition, accumulation and toxicity of iron fed as iron (II) sulfate oras sodium iron EDTA in rats", FOOD CHEM T, 39(3), 2001, pp. 261-269

Abstract

A study was performed to provide data on the disposition, accumulation acid toxicity of sodium iron EDTA in comparison with iron (II) sulfate in ratson administration via the diet for 31 and 61 days. Clinical signs, body weights, food consumption, food conversion efficiency, hematology, clinical chemistry and pathology of selected organs were used as criteria for disclosing possible harmful effects. Determination of iron and total iron binding capacity in blood plasma and cion-hems iron analysis in liver, spleen and kidneys were used to assess the disposition and accumulation of iron originating from sodium iron EDTA or iron (TI) sulfate. It was concluded that, under the conditions of the present study. iron is accumulated from the diet in liver, spleen and kidneys in a dose-dependent manner, and iron derived from FeEDTA is taken up and/or accumulated less efficiently in liver and spleen than iron from FeSO4. Moreover, feeding iron up to 11.5 and 11.2 mg/kg body weight/day, derived from FeSO4 and FeEDTA, respectively, did not resultin tissue iron excess nor in any other toxicologically significant effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:10:07