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Titolo:
Short-term effects of three continuous hormone replacement therapy regimens on platelet tritiated imipramine binding and mood scores: a prospective randomized trial
Autore:
Bukulmez, O; Al, A; Gurdal, H; Yarali, H; Ulug, B; Gurgan, T;
Indirizzi:
Univ Hacettepe, Sch Med, Dept Obstet & Gynecol, TR-06100 Ankara, Turkey Univ Hacettepe Ankara Turkey TR-06100 & Gynecol, TR-06100 Ankara, Turkey Ankara Univ, Sch Med, Dept Pharmacol, TR-06100 Ankara, Turkey Ankara UnivAnkara Turkey TR-06100 pt Pharmacol, TR-06100 Ankara, Turkey Ankara Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 ept Psychiat, TR-06100 Ankara, Turkey
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 4, volume: 75, anno: 2001,
pagine: 737 - 743
SICI:
0015-0282(200104)75:4<737:SEOTCH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL WOMEN; SEROTONIN UPTAKE; H-3 IMIPRAMINE; DEPRESSED-PATIENTS; MENOPAUSAL WOMEN; ESTROGEN; SYMPTOMS; SITES; ESTRADIOL; PROGESTIN;
Keywords:
hormone replacement therapy; platelet-tritiated imipramine binding; mood; conjugated estrogens; medroxyprogesterone acetate; tibolone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bukulmez, O Kaptanpasa Sokak 14-6, TR-06780 Ankara, Turkey Kaptanpasa Sokak 14-6 Ankara Turkey TR-06780 Ankara, Turkey
Citazione:
O. Bukulmez et al., "Short-term effects of three continuous hormone replacement therapy regimens on platelet tritiated imipramine binding and mood scores: a prospective randomized trial", FERT STERIL, 75(4), 2001, pp. 737-743

Abstract

Objective: To evaluate the effects of continuous hormone replacement therapy (HRT) regimens on platelet-tritiated (H-3-) imipramine binding (Bmax) and mood. Design: Prospective randomized study. Setting: University hospital. Patient(s): Sixty postmenopausal patients. Intervention(s): Randomization to 3 months of dairy treatment with tibolone and conjugated equine estrogen (CEE) .625 mg combined either with 2.5 or 5 mg of medroxyprogesterone acetate (MPA). The inclusion criteria-matched patients declined for HRT were prescribed daily alendronate. Pre- and posttreatment brood sampling for Bmax and mood evaluation with the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI) were done. Main Outcome Measure(s): Pre- and posttreatment Bmax and mood scores. Result(s): As compared with baseline, both CEE+MPA regimens and tibolone significantly increased Bmax. The comparisons of percent change from baseline Bmax for the CEE+MPA and tibolone groups were similar. All three HRT regimens improved the BDI significantly, while there were no significant changes in the STAI. In the alendronate group, there were no significant changes in both pre- and posttreatment Bmax and mood scores. Conclusion(s): Continuous treatment with CEE + MPA and tibolone increases platelet H-3-imipramine binding and improves mood. Mood-enhancing effects of tibolone may occur through the serotonergic system, as is the case with estrogen. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:51:57