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Titolo:
Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon)
Autore:
de Jong, D; Macklon, NS; Eijkemans, MJC; Mannaerts, BMJL; Bennink, HJTC; Fauser, BCJM;
Indirizzi:
Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3015 GD GD Rotterdam, Netherlands Erasmus Univ, Med Ctr, Dept Publ Hlth, NL-3015 GD Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3015 GD GD Rotterdam, Netherlands
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 4, volume: 75, anno: 2001,
pagine: 688 - 693
SICI:
0015-0282(200104)75:4<688:DOTDOM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL MENSTRUAL-CYCLE; LUTEINIZING-HORMONE; GRANULOSA-CELLS; ESTROGEN BIOSYNTHESIS; NAL-GLU; CETRORELIX; GROWTH; WOMEN; HYPERSTIMULATION; SUPPRESSION;
Keywords:
follicle development; FSH; GnRH antagonist; ganirelix; two-gonadotropin two-cell concept; estradiol; androstenedione; FSH; LH; total follicular surface area; IVF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Fauser, BCJM Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med,Dr Molewaterplein 40, NL-3015 GD Rotterdam, Netherlands Erasmus Univ Dr Molewaterplein 40 Rotterdam Netherlands NL-3015 GD
Citazione:
D. de Jong et al., "Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon)", FERT STERIL, 75(4), 2001, pp. 688-693

Abstract

Objective: To investigate relations between dose of GnRH antagonist and follicular phase characteristics. Design: Randomized controlled multicenter trial. Setting: Tertiary referral fertility centers. Patient(s): Three hundred and twenty-nine IVF patients. Intervention(s): Ovarian stimulation for IVF with recombinant FSH startingon cycle day 2. From cycle day 7 onwards, cotreatment was provided with 0.0625, 0.125. 0.25, 0.5, 1.0, or 2.0 mg/d GnRH antagonist. Main Outcome Measure(s): Number of follicles, total follicular surface area, gonadotropin, and serum steroid concentrations. Result(s): In 311 patients, similar follicular growth was observed in all treatment groups. FSH levels increased during the follicular phase. Late follicular phase LH, androstenedione (AD), and E, levels showed a GnRH antagonist dose-related decrease (P<0.05). Late follicular phase E, levels correlated with total follicular surface area, AD, LH, and FSH (all P<0.001), increasing GnRH antagonist doses exhibited additional suppressive action on E,levels. Conclusion(s): Follicular growth was unaffected by the dose of GnRH antagonist. A rise in follicular phase FSH serum concentrations during the follicular phase, largely related to exogenous FSH, enabled ongoing follicular growth in all treatment groups. The effect of GnRH;l antagonist on late follicular phase E, levels could not be exclusively attributed to suppression ofLH, (C) 2001 1 by American Society far Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 18:08:28