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Titolo:
Fertility options for female cancer patients: facts and fiction
Autore:
Posada, MN; Kolp, L; Garcia, JE;
Indirizzi:
Johns Hopkins Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Sch Med, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 ch Med, Baltimore, MD 21287 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 4, volume: 75, anno: 2001,
pagine: 647 - 653
SICI:
0015-0282(200104)75:4<647:FOFFCP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; HUMAN OVARIAN TISSUE; BONE-MARROW TRANSPLANTATION; MOUSE PRIMORDIAL FOLLICLES; LONG-TERM CULTURE; IN-VITRO GROWTH; HODGKINS-DISEASE; HUMAN OOCYTES; INDUCED GONADOTOXICITY; FOLLICULAR DEVELOPMENT;
Keywords:
cancer therapy; ovarian tissue; GnRH analog; cryopreservation; transplantation; culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Posada, MN Johns Hopkins Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Sch Med, 600 N Wolfe St,Phipps 249, Baltimore, MD 21287 USA Johns Hopkins Univ 600 N Wolfe St,Phipps 249 Baltimore MD USA 21287
Citazione:
M.N. Posada et al., "Fertility options for female cancer patients: facts and fiction", FERT STERIL, 75(4), 2001, pp. 647-653

Abstract

Objective: To review the latest progress in the prevention of ovarian failure induced by chemo/radiotherapy, as well as the latest advances in culture technology and transplantation of frozen-thawed ovarian tissue. Design: The English-language literature was searched with PubMed and related references. Conclusion(s): The development of combination chemotherapy and radiotherapy has improved the long-term survival of young cancer patients who are thenfrequently faced with iatrogenic ovarian failure and its consequences. Theuse of prior and concomitant GnRH analogs with chemotherapy offers encouraging results in animal studies with regard to prevention of ovarian failure. Adequately controlled research projects are needed to define the utility of GnRHa cotreatment in women cancer patients exposed to prolonged chemotherapy. Ovarian tissue cryopreservation is the optimal procedure for folliclebanking. Theoretic options include returning the banked tissue back to theoriginal pedicle so that pregnancy could be achieved naturally. Alternatively, the tissue can be grafted to a heterotopic site, either as an autograft (i.e., rectus abdominis muscle sheath) or as a xenograft (i.e., immunodeficient mice). Follicles could also be grown in vitro. Until reliable ovarian culture technology becomes available, autologous transplantation offers the best prospect of using frozen-thawed ovarian tissue. A primary concern, however, is the issue of microscopic metastatic disease to the ovary and the possibility of tumor reimplantation. Areas of research should focus on optimizing the freeze/thaw procedure for ovarian tissue, minimizing the ischemia-reperfusion injury after transplantation, and detecting minimal residual disease in ovarian tissue grafts. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:56:57