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Titolo:
The Rev/Rex homolog HERV-K cORF multimerizes via a C-terminal domain
Autore:
Boese, A; Galli, U; Geyer, M; Sauter, M; Mueller-Lantzsch, N;
Indirizzi:
Univ Kliniken Homburg, Abt Virol, Inst Med Mikrobiol & Hyg, D-66421 Homburg, Germany Univ Kliniken Homburg Homburg Germany D-66421 , D-66421 Homburg, Germany Univ Calif San Francisco, Mt Zion Canc Res Inst, San Francisco, CA 94115 USA Univ Calif San Francisco San Francisco CA USA 94115 ancisco, CA 94115 USA
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 493, anno: 2001,
pagine: 117 - 121
SICI:
0014-5793(20010330)493:2-3<117:TRHHCM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ENDOGENOUS RETROVIRUSES; NUCLEAR-LOCALIZATION SIGNAL; ZINC-FINGER PROTEIN; HTDV/HERV-K; IMPORTIN-BETA; VIRUS TYPE-1; REV; ENCODES; IDENTIFICATION; EXPORT;
Keywords:
human endogenous retrovirus K cORF; Rev/Rex; oligomerization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mueller-Lantzsch, N Univ Kliniken Homburg, Abt Virol, Inst Med Mikrobiol &Hyg, Haus 47, D-66421 Homburg, Germany Univ Kliniken Homburg Haus 47 Homburg Germany D-66421
Citazione:
A. Boese et al., "The Rev/Rex homolog HERV-K cORF multimerizes via a C-terminal domain", FEBS LETTER, 493(2-3), 2001, pp. 117-121

Abstract

Expression of human endogenous retrovirus K (HERV-K) is associated with germ-cell neoplasia, HERV-K encodes a protein of the Rev/Rex family, cORF that supports cellular transformation and binds the promyelocytic leukemia zinc finger (PLZF) protein implicated in spermatogenesis, Rev/Rex function invariably depends on multimerization. Here we show that cORF likewise self-associates to form higher-order oligomers. Amino acids (aa) 47-87 in cORF aresufficient, aa 75-87 essential for self-association. Consistently, this domain is predicted to form a hydrophobic alpha -helix that may represent an oligomerization interface, The existence of a dimerization-competent cORF mutant lacking PLZF-hinding activity (cORF47-87) suggests a way of dominant negative inhibition of the proposed tumor susceptibility factor cORF. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:27:10