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Titolo:
Lysophosphatidic acid-independent platelet activation by low-density lipoprotein
Autore:
Korporaal, SJA; Relou, IAM; van Rijn, HJM; Akkerman, JWN;
Indirizzi:
Univ Utrecht, Med Ctr, Biomembrane Inst, Dept Haematol,Lab Thrombosis & Haemostasis, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Clin Chem, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 494, anno: 2001,
pagine: 121 - 124
SICI:
0014-5793(20010406)494:1-2<121:LAPABL>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHASE PROTEIN EXPRESSION; OXIDIZED LDL; INTEGRIN ALPHA(IIB)BETA(3); ENDOTHELIAL-CELLS; BLOOD-PLATELETS; FIBRINOGEN; KINASE; HYPERCHOLESTEROLEMIA; SECRETION; AFFINITY;
Keywords:
lysophosphatidic acid; low-density lipoprotein; N-palmitoyl-L-serine-phosphoric acid; alpha(IIb)beta(3);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Korporaal, SJA Univ Utrecht, Med Ctr, Biomembrane Inst, Dept Haematol,Lab Thrombosis & Haemostasis, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands Univ Utrecht Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
S.J.A. Korporaal et al., "Lysophosphatidic acid-independent platelet activation by low-density lipoprotein", FEBS LETTER, 494(1-2), 2001, pp. 121-124

Abstract

Mildly oxidized low-density lipoprotein activates platelets through lysophosphatidic acid (LPA), Hence, the platelet-activating properties attributedto native low-density lipoprotein (nLDL) might be caused by LPA contamination, We show that nLDL enhances thrombin receptor-activating peptide (TRAP)-induced fibrinogen binding to alpha (IIb)beta (3). The LPA receptor blocker N-palmitoyl-L-serine-phosphoric acid did not affect nLDL-enhanced fibrinogen binding induced by TRAP, but reduced TRAP-induced binding. cAMP and inhibitors of protein kinase C and Ca2+ rises completely blocked ligand binding by TRAP and nLDL/TRAP, Inhibitors of p38(MAPK) and ADP secretion interfered only partially. Blockade of Rho-kinase increased ligand binding 2-3-fold. We conclude that nLDL enhances TRAP-induced fibrinogen binding independent of LPA. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:55:04