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Titolo:
Antioxidant strategies for neurodegenerative diseases
Autore:
Contestabile, A;
Indirizzi:
Univ Bologna, Dept Biol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 na, Dept Biol, I-40126 Bologna, Italy
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 4, volume: 11, anno: 2001,
pagine: 573 - 585
SICI:
1354-3776(200104)11:4<573:ASFND>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINKGO-BILOBA EXTRACT; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; N-ACETYLCYSTEINE; NITRIC-OXIDE; HIPPOCAMPAL-NEURONS; BRAIN; GLUTATHIONE; DAMAGE; RATS;
Keywords:
antioxidants; biotechnology; enzyme inhibitors; pharmaceutical compositions; ROS scavengers;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Contestabile, A Univ Bologna, Dept Biol, Via Selmi 3, I-40126 Bologna, Italy Univ Bologna Via Selmi 3 Bologna Italy I-40126 gna, Italy
Citazione:
A. Contestabile, "Antioxidant strategies for neurodegenerative diseases", EXPERT OP T, 11(4), 2001, pp. 573-585

Abstract

A very large body of evidence supports the involvement of oxidative stressin neurodegenerative pathologies. Therefore, therapies based on administration of antioxidant and reactive oxygen species (ROS) scavenging substanceshave been widely proposed for treatment of both acute and chronic neuropathological diseases. In the present review, several recent patents (mostly from 1998 - 2000) based on the proposed use of antioxidant strategies to treat neurodegenerative diseases are considered. In particular, the following classes of patents are examined: patents for novel antioxidant and ROS scavengers, pharmaceutical compositions in which antioxidant and ROS scavengersare claimed together with other pharmacological tools, patents based on new biotechnological and gene therapy approaches, and patents based on enzymatic manipulation of ROS production and elimination. In the comment, the most promising perspectives stemming from these patents are discussed; in particular: (i.) the usefulness of pharmaceutical compositions able to counteract the deleterious effects of excessive amounts of free radicals originating from different cellular process, without blocking the physiological beneficial action of their controlled production; (ii.) the potential beneficialeffects of combining antioxidant treatments with modulation of the activity of receptors for excitatory amino acid and modulation of calcium levels: (iii.) the tremendous future impact of biotechnological and gene therapy techniques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:38:57