Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Advances in potential therapeutic uses of inhibitors of CNS selective amino acid transporters
Autore:
Armer, RE; Miller, DJ;
Indirizzi:
Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland Organon Labs Ltd Newhouse Scotland ML1 5SH m, Newhouse ML1 5SH, Scotland
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 4, volume: 11, anno: 2001,
pagine: 563 - 572
SICI:
1354-3776(200104)11:4<563:AIPTUO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA UPTAKE INHIBITORS; GLUTAMATE TRANSPORTER; NIPECOTIC ACID; RAT-BRAIN; DERIVATIVES; EXPRESSION; TAURINE; SCHIZOPHRENIA; PHARMACOLOGY; RECEPTOR;
Keywords:
arginine; CNS application; GABA; glutamate; glycine; neurodegeneration; proline; psychiatry; taurine; transport inhibitor; uptake inhibitor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Armer, RE Organon Labs Ltd, Dept Med Chem, Newhouse ML1 5SH, Scotland Organon Labs Ltd Newhouse Scotland ML1 5SH e ML1 5SH, Scotland
Citazione:
R.E. Armer e D.J. Miller, "Advances in potential therapeutic uses of inhibitors of CNS selective amino acid transporters", EXPERT OP T, 11(4), 2001, pp. 563-572

Abstract

CNS selective amino acid transporters provide an important function in maintaining tonic extracellular levels of amino acids that act as neurotransmitters, synaptic modulators or neurotransmitter precursors. Small molecule inhibitors of these transporters have been postulated and in some cases demonstrated to be useful in the treatment of a range of CNS driven disorders, such as epilepsy, anxiety, psychosis, depression, pain and neurodegenerative disease. Although much of the research to date in this field has focussedon inhibition of the GABA transporters, more recent reports have also generated interest in modulation of glycine, glutamate and proline transporters. This review covers the recent patent literature in this emerging field ofCNS research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:48:14