Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Novel treatments for bipolar disorder
Autore:
Bowden, CL;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Psychiat, San Antonio, TX 78229 USA Univ Texas San Antonio TX USA 78229 t Psychiat, San Antonio, TX 78229 USA
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 4, volume: 10, anno: 2001,
pagine: 661 - 671
SICI:
1354-3784(200104)10:4<661:NTFBD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; ACUTE MANIA; MAINTENANCE TREATMENT; DIVALPROEX SODIUM; I DISORDER; LITHIUM; CARBAMAZEPINE; VALPROATE; EFFICACY;
Keywords:
antipsychotic; bipolar; depression; divalproex; lamotrigine; manic-depressive; treatment; valproate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Bowden, CL Univ Texas, Hlth Sci Ctr, Dept Psychiat, 7703 Floyd Curl Dr,Mail Code 7792, San Antonio, TX 78229 USA Univ Texas 7703 Floyd Curl Dr,Mail Code 7792 San Antonio TX USA 78229
Citazione:
C.L. Bowden, "Novel treatments for bipolar disorder", EXPERT OP I, 10(4), 2001, pp. 661-671

Abstract

Treatments other than lithium have recently emerged as equally important in the management of bipolar disorder. The spectrum of efficacy of newer treatments differs from lithium and among the novel drug treatments valproate,generally used as the better tolerated divalproex form, principally benefits manic symptomatology both acutely and in prophylaxis. Atypical antipsychotic drugs have demonstrated efficacy in reducing acute manic symptoms. No controlled evidence of efficacy in prophylaxis has been published. Lamotrigine has demonstrated efficacy in both acute bipolar depression and maintenance efficacy in rapid cycling bipolar patients, especially those patients with bipolar II disorder, which is principally manifested as depression. Randomised, double-blind, placebo-controlled studies provide good evidence that regimens of risperidone or olanzapine in combination with lithium or valproate provide greater improvement in acute mania than the mood stabilisers alone. Similarly, valproate combined with antipsychotics provided greater improvement in mania than antipsychotic medication alone and resulted in lower dosage of the antipsychotic medication. A positive but unclear placebo-controlled study of omega-3 fatty acids added to lithium in bipolar disorderneeds confirmation in standard clinical trial paradigms. Several other drugs that were reported as beneficial in various facets of bipolar disorder in open trials have not differed from placebo when studied in randomised, placebo-controlled trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:04:16