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Titolo:
Adenosine in the treatment of stroke: yes, maybe, or absolutely not?
Autore:
von Lubitz, DKJE;
Indirizzi:
Univ Michigan, Med Ctr, Dept Emergency Med, Emergency Med Res Labs, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ed Res Labs, Ann Arbor, MI 48109 USA
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 4, volume: 10, anno: 2001,
pagine: 619 - 632
SICI:
1354-3784(200104)10:4<619:AITTOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT FOCAL ISCHEMIA; NITRIC-OXIDE PRODUCTION; POSTISCHEMIC RAT-BRAIN; LONG-TERM POTENTIATION; MIDDLE CEREBRAL-ARTERY; A(1) RECEPTOR-BINDING; NECROSIS-FACTOR-ALPHA; A(3) RECEPTORS; A(2A) RECEPTORS; KINASE INHIBITOR;
Keywords:
adenosine; adenosine receptors; cerebral ischaemia; stroke; treatment;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
174
Recensione:
Indirizzi per estratti:
Indirizzo: von Lubitz, DKJE Univ Michigan, Med Ctr, Dept Emergency Med, Emergency MedRes Labs, TC-B1354-0303,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan TC-B1354-0303,1500 E Med Ctr Dr Ann Arbor MI USA 48109
Citazione:
D.K.J.E. von Lubitz, "Adenosine in the treatment of stroke: yes, maybe, or absolutely not?", EXPERT OP I, 10(4), 2001, pp. 619-632

Abstract

Agonist stimulation of adenosine A(1) receptors has been consistently shown to result in reduction of brain damage following experimentally induced global and focal brain ischaemia in animals. Unsurprisingly, the use of adenosine A(1) receptors as targets for the development of clinical therapeutics suitable for treatment of ischaemic brain disorders has been suggested bymany authors. The latest studies of adenosine and its receptors indicate that adenosine-mediated actions might be far more complex than originally anticipated, casting some doubt about the rapid development of stroke treatment based on adenosine. This review discusses the possible role of adenosinereceptor subtypes (A(1), A(2) and A(3)) in the context of their potential as therapeutics in stroke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:42:46