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Titolo:
Fibroblast growth factor inhibits locomotor activity as well as feeding behavior of rats
Autore:
Hotta, M; Kuriyama, H; Arai, K; Takano, K; Shibasaki, T;
Indirizzi:
Tokyo Womens Med Univ, Sch Med, Inst Clin Endocrinol, Dept Med, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 Dept Med, Tokyo 1628666, Japan Nippon Med Sch, Dept Physiol, Tokyo 1138602, Japan Nippon Med Sch Tokyo Japan 1138602 h, Dept Physiol, Tokyo 1138602, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 416, anno: 2001,
pagine: 101 - 106
SICI:
0014-2999(20010323)416:1-2<101:FGFILA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CENTRAL-NERVOUS-SYSTEM; NEUROPEPTIDE-Y; FOOD-INTAKE; INGESTIVE BEHAVIOR; NEURONS; LOCALIZATION; SURVIVAL; BRAIN; SLEEP;
Keywords:
FGF (fibroblast growth factor); locomotor activity; feeding behavior; intracerebroventricular injection; osmotic pump;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Hotta, M Tokyo Womens Med Univ, Sch Med, Inst Clin Endocrinol, Dept Med, 8-1 KawadaCho, Tokyo 1628666, Japan Tokyo Womens Med Univ 8-1 Kawada Cho Tokyo Japan 1628666 , Japan
Citazione:
M. Hotta et al., "Fibroblast growth factor inhibits locomotor activity as well as feeding behavior of rats", EUR J PHARM, 416(1-2), 2001, pp. 101-106

Abstract

The effects of acute and chronic intracerebroventricular (i.c.v.) administration of basic fibroblast growth factor (bFGF) on behavior were examined in free-feeding rats. An i.c.v. injection of bFGF induced behavioral changes, such as an increase in resting and decreases in grooming, moving, and food intake at a dose of 20 or 50 ng. These effects appeared at 4-5 h and lasted at least 11 h after the injection. These changes, as well as inhibition of body weight gain, were also found during a B-day period of chronic i.c.v. infusion of bFGF at a dose of 20 ng/h. These results indicate that bFGF as both bolus i.c.v. injection and chronic i.c.v. infusion inhibits not onlyfeeding behavior but also locomotor activity in rats. It is suggested thatthe inhibitory effect of bFGF on food intake may be in part ascribed to the suppression of behavior by bFGF. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:34:42