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Titolo:
Correlations between serum assays of human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) and pre-eclampsia or intrauterine growth restriction (IUGR) among nulliparas younger than 38 years
Autore:
Merviel, P; Muller, F; Guibourdenche, J; Berkane, N; Gaudet, R; Breart, G; Uzan, S;
Indirizzi:
Hop Tenon, Serv Gynecol Obstet & Med Reprod, F-75020 Paris, France Hop Tenon Paris France F-75020 bstet & Med Reprod, F-75020 Paris, France Univ Paris 05, Fac Sci Pharmaceut & Biol, INSERM, U427, F-75270 Paris 06, France Univ Paris 05 Paris France 06 ol, INSERM, U427, F-75270 Paris 06, France Hop Tenon, UPRES Physiol Implantat & Dev, EA 2396, F-75020 Paris, France Hop Tenon Paris France F-75020 tat & Dev, EA 2396, F-75020 Paris, France Hop Ambroise Pare, Serv Biochim, F-92100 Boulogne, France Hop Ambroise Pare Boulogne France F-92100 chim, F-92100 Boulogne, France Hop Robert Debre, Serv Biochim, F-75019 Paris, France Hop Robert Debre Paris France F-75019 erv Biochim, F-75019 Paris, France Hop Tenon, INSERM, U149, F-75020 Paris, France Hop Tenon Paris France F-75020 enon, INSERM, U149, F-75020 Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
fascicolo: 1, volume: 95, anno: 2001,
pagine: 59 - 67
SICI:
0301-2115(200103)95:1<59:CBSAOH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DOSE ASPIRIN; PREGNANCY-INDUCED HYPERTENSION; FETAL GROWTH; RANDOMIZED TRIAL; PREECLAMPSIA; PREVENTION; COMPLICATIONS; ASSOCIATION; RETARDATION; DOPPLER;
Keywords:
human chorionic gonadotrophin (hCG); human placental lactogenic hormone (hPL); pre-eclampsia; intrauterine growth retardation; pregnancy-induced hypertension; Doppler;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Merviel, P Hop Tenon, Serv Gynecol Obstet & Med Reprod, 4 Rue Chine, F-75020 Paris, France Hop Tenon 4 Rue Chine Paris France F-75020 75020 Paris, France
Citazione:
P. Merviel et al., "Correlations between serum assays of human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) and pre-eclampsia or intrauterine growth restriction (IUGR) among nulliparas younger than 38 years", EUR J OB GY, 95(1), 2001, pp. 59-67

Abstract

Objective: To study the relation between serum human chorionic gonadotrophin (hCG) levels measured at 15-18 weeks and gestational disorders, assess their correlation with the artery uteroplacental Doppler (AUD) at 24 weeks among nulliparas, and assess the predictivity of the hCG/hPL (human placental lactogen) ratio for pre-eclampsia. Study Design: Retrospective study of two groups of women younger than 38 years old: one with an elevated serum hCG level (2 MoM (multiples of the median) or more) and a normal fetal karyotype (group A), and the other with a lower hCG level (group B). Within each group, we studied the nulliparas separately (respectively groups AO and BO). We analyzed the double screening, elevated hCG levels with abnormal AUD, for the predicting of hypertensive disorders. Results: Elevated hCG levels were significantly (p<0.05) more prevalent among women who developed gestational diabetes (groups A and AO) and among nulliparas with pregnancy-induced hypertension and pre-eclampsia (AO). Among nulliparas, the combination ofthe hCG assay and a Subsequent Doppler increased the positive predictive value (PPV) of the assay from 19 to 75%, without reducing its negative predictive value (NPV) for gestational vascular disorders. The hCG/hPL ratio didnot improve the predictivity of the hCG assay alone for pre-eclampsia. Conclusions: An hCG level of 2 MoM or more; at 15-18 weeks identifies a group of women at risk of gestational vascular disorders; it therefore ought to lead to an AUD at 24 weeks. This double screening should be able to define apopulation of women at risk of developing a hypertensive disorder, who could thus benefit from a preventive treatment, as aspirin. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:08:03