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Titolo:
INTRALUMINAL COLONIC RELEASE OF IMMUNOREACTIVE TUMOR-NECROSIS-FACTOR IN CHRONIC ULCERATIVE-COLITIS
Autore:
CASELLAS F; PAPO M; GUARNER F; ANTOLIN M; ARMENGOL JR; MALAGELADA JR;
Indirizzi:
HOSP GEN VALLE HEBRON,DIGEST SYST RES UNIT,PSO VALL DHEBRON S-N E-08035 BARCELONA SPAIN
Titolo Testata:
Clinical science
fascicolo: 4, volume: 87, anno: 1994,
pagine: 453 - 458
SICI:
0143-5221(1994)87:4<453:ICROIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; FACTOR-ALPHA; CELLS; CACHECTIN; MEDIATOR;
Keywords:
COLONIC PERFUSION; CYTOKINES; EICOSANOIDS; LEUKOTRIENES; PROSTAGLANDINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F. Casellas et al., "INTRALUMINAL COLONIC RELEASE OF IMMUNOREACTIVE TUMOR-NECROSIS-FACTOR IN CHRONIC ULCERATIVE-COLITIS", Clinical science, 87(4), 1994, pp. 453-458

Abstract

1. Tumour necrosis factor is a proinflammatory macrophage-derived polypeptide cytokine. Its participation in disease processes has been usually inferred from data obtained from experiments in vitro or from measurements of its plasma circulating levels. To investigate its role inchronic ulcerative colitis, we have quantified in vivo the steady-state release of tumour necrosis factor into the colonic lumen. 2. We studied 19 patients with untreated active ulcerative colitis and seven patients with irritable bowel syndrome as controls. A group of seven patients with active ulcerative colitis were studied before and after 4 weeks on treatment with oral 5-aminosalicylic acid. By means of an intracolonic double-lumen perfusion tube, an isotonic solution was continuously infused 50 cm from the anal verge at a rate of 5 ml/min, and wasrecovered 30 cm distally by siphonage. Effluents were assayed for tumour necrosis factor by a specific e.l.i.s.a. and for prostaglandin E(2) and leukotriene B-4 by specific r.i.a.s. 3. The intracolonic releaseof tumour necrosis factor was undetectable in patients with irritablebowel syndrome, whereas measurable release occurred in 15 out of 19 patients with active ulcerative colitis (P<0.01). Prostaglandin E(2) and leukotriene B-4 release were also increased in active ulcerative colitis by comparison with irritable bowel syndrome (P<0.01). Five out ofseven patients with colitis improved with fi-aminosalicylic acid treatment, and tumour necrosis factor release became undetectable or decreased markedly (P<0.05 compared with before treatment). However, tumournecrosis factor release remained high in the non-responder patients. 4. These findings indicate that intracolonic immunoreactive tumour necrosis factor release is enhanced in active chronic ulcerative colitis,becoming undetectable when mucosal lesions are healed. These results suggest that the luminal release of tumour necrosis factor may serve as an objective index of inflammatory activity in patients with chroniculcerative colitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:13:28