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Titolo:
Effects of verapamil in normal elderly individuals with left ventricular diastolic dysfunction
Autore:
Hung, MJ; Cherng, WJ; Wang, CH; Kuo, LT;
Indirizzi:
Chang Gung Mem Hosp, Cardiol Sect, Dept Med, Keelung 204, Taiwan Chang Gung Mem Hosp Keelung Taiwan 204 ct, Dept Med, Keelung 204, Taiwan
Titolo Testata:
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
fascicolo: 2, volume: 18, anno: 2001,
pagine: 123 - 129
SICI:
0742-2822(200102)18:2<123:EOVINE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; DOPPLER-ECHOCARDIOGRAPHY; DISEASE; AGE; ABNORMALITIES; CONTRACTION; PERFORMANCE; DILTIAZEM; VELOCITY;
Keywords:
verapamil; aging; diastolic function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Cherng, WJ Chang Gung Mem Hosp, Cardiol Sect, Dept Med, 222 Mai Chin Rd, Keelung 204,Taiwan Chang Gung Mem Hosp 222 Mai Chin Rd Keelung Taiwan 204 ,Taiwan
Citazione:
M.J. Hung et al., "Effects of verapamil in normal elderly individuals with left ventricular diastolic dysfunction", ECHOCARDIOG, 18(2), 2001, pp. 123-129

Abstract

Treatment with oral verapamil for 3 to 4 days has been found to enhance left ventricular (LV) diastolic filling in elderly subjects as assessed by radionuclide angiography. However there are no Doppler echocardiographic studies to assess the long-term effect of verapamil in normal elderly subjects. Thirteen healthy elderly subjects (mean age, 64 +/- 7 years; 8 men and 5 women) with LV diastolic dysfunction underwent this placebo-controlled cross-over trial. The effect of verapamil on LV diastolic function was assessed by treadmill exercise test and Doppler echocardiography at baseline, and after each 3-month treatment period (placebo or verapamil 120 mg once daily),separated by a 1-week washout period before cross-over. Blood pressure, heart rate, LV ejection fraction, LV mass, and cardiac output were unaltered by placebo or verapamil. The exercise time was similar at baseline (11.4 +/- 2.4 min) and after placebo treatment (11.4 +/- 2.3 min) but significantlyincreased (P < 0.05) after verapamil treatment (12.3 <plus/minus> 2.0 min). The ratio of mitral A wave duration/pulmonary venous atrial systolic reversal duration increased after verapamil treatment (1.12 +/- 0.08) compared to placebo (0.93 +/- 0.06 P < 0.05) and baseline (0.89 <plus/minus> 0.09), which had similar durations. The isovolumic relaxation time (IVRT) was significantly decreased (P < 0.05) from 85 <plus/minus> 13 msec at baseline and87 +/- 13 msec with placebo to 73 +/- 9 msec with verapamil. The results of this study suggest that in normal elderly patients with Doppler evidence of diastolic dysfunction, 3 months treatment with verapamil can increase exercise tolerance and improve LV diastolic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:47:47