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Titolo:
Paradoxical effects of ketamine on the memory of fetuses of different ages
Autore:
Mickley, GA; Remmers-Roeber, DR; Dengler, CM; Kenmuir, CL; Crouse, C;
Indirizzi:
Baldwin Wallace Coll, Dept Psychol, Berea, OH 44017 USA Baldwin Wallace Coll Berea OH USA 44017 Dept Psychol, Berea, OH 44017 USA Baldwin Wallace Coll, Neurosci Program, Berea, OH 44017 USA Baldwin Wallace Coll Berea OH USA 44017 osci Program, Berea, OH 44017 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 127, anno: 2001,
pagine: 71 - 76
SICI:
0165-3806(20010329)127:1<71:PEOKOT>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR; RAT-BRAIN; ANTAGONIST KETAMINE; TASTE-AVERSION; PERINATAL RATS; NERVOUS-SYSTEM; EXPRESSION; SYNAPSE; CURRENTS; PROTEINS;
Keywords:
conditioned taste aversion; fetus; neonate; rat; memory; saccharin; lithium chloride; development; ketamine; NMDA; learning; ketamine paradox;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Mickley, GA Baldwin Wallace Coll, Dept Psychol, 275 Eastland Rd,Carnegie Hall, Berea, OH 44017 USA Baldwin Wallace Coll 275 Eastland Rd,Carnegie HallBerea OH USA 44017
Citazione:
G.A. Mickley et al., "Paradoxical effects of ketamine on the memory of fetuses of different ages", DEV BRAIN R, 127(1), 2001, pp. 71-76

Abstract

Brain N-methyl-D-aspartate (NMDA) glutamate receptors have been implicatedas important mediators of both learning and neuronal development. The current study investigated how ketamine (a well-known NMDA-receptor blocking drug) influences taste-mediated conditioned motor responses (CMRs) in perinatal rats. Darns pregnant with either embryonic day Is (E18) or E19 rat fetuses were injected with 0 or 100 mg/kg ketamine HCl (i.p.): One-half hour later, a reversible spinal block was performed on the dam and fetuses receivedoral lavage with 10 mul, 0.3% saccharin (SAC) or water (control) in utero. After the oral injection, fetuses received either a saline (control) or lithium chloride (LiCl) injection (81 mg/kg, i.p.). The uterus was replaced and, 2 days later (E20 or E21), some rats received oral lavage with SAG. Other litters were born via normal vaginal delivery or Cesarean section and orally exposed to SAC on post-natal day 3 (P3). Motor responses were observedimmediately after the oral lavage of SAG. If SAC had been paired with LiClin utero, pups generally exhibited conditioned suppression of orofacial movements (as compared to controls). Ketamine significantly attenuated this taste-mediated CMR of animals conditioned on E19. However, the same treatments did not disrupt CMRs of rats treated with ketamine before CS-US pairing on E18. Our findings indicate an age-dependent role for NMDA receptors in the formation of CMRs in perinatal rats. (C) 2001 Elsevier Science BN; All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:40:40