Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Self-assembly of poly(ethylene glycol)-based block copolymers for biomedical applications
Autore:
Otsuka, H; Nagasaki, Y; Kataoka, K;
Indirizzi:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Tokyo 1138656, Japan Univ Tokyo Tokyo Japan 1138656 Engn, Dept Mat Sci, Tokyo 1138656, Japan Sci Univ Tokyo, Dept Mat Sci & Technol, Noda, Chiba 2788510, Japan Sci Univ Tokyo Noda Chiba Japan 2788510 chnol, Noda, Chiba 2788510, Japan
Titolo Testata:
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
fascicolo: 1, volume: 6, anno: 2001,
pagine: 3 - 10
SICI:
1359-0294(200102)6:1<3:SOPGBC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIBLOCK COPOLYMERS; ONE END; PROTEIN ADSORPTION; REACTIVE MICELLES; OXIDE SURFACES; HYDROXYL GROUP; FORMYL GROUP; POLYMER; ATTACHMENT; CELLS;
Keywords:
heterobifunctional block copolymer; poly(ethylene glycol); poly (lactide); surface modification; polymeric micelle; bio-specific recognition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Kataoka, K Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Hongo 7-3-1, Tokyo 1138656, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1138656 okyo 1138656, Japan
Citazione:
H. Otsuka et al., "Self-assembly of poly(ethylene glycol)-based block copolymers for biomedical applications", CURR OP COL, 6(1), 2001, pp. 3-10

Abstract

Nanostructure fabrication from block copolymers is discussed in this review paper. Particularly, novel approaches for the construction of functionalized poly(ethylene glycol) (PEG) layers on surfaces were focused to attain the specific adsorption of a target protein through PEG-conjugated ligands with a minimal non-specific adsorption of other proteins. Furthermore, surface organization of block copolymer micelles with cross-linking cores was described from the standpoint of preparation of a new functional surface-coating with a unique macromolecular architecture. The micelle-attached surfaceand the thin hydrogel layer made by layered micelles exhibited non-foulingproperties and worked as a reservoir for hydrophobic reagents. These PEG-functionalized surface in brush form or in micelle form can be used in diverse fields of medicine and biology to construct high-performance medical devices including scaffolds for tissue engineering and matrices for drug delivery systems. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:39:01