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Titolo:
Development of response-selective agonists of human C5a anaphylatoxin: Conformational, biological, and therapeutic considerations
Autore:
Taylor, SM; Sherman, SA; Kirnarsky, L; Sanderson, SD;
Indirizzi:
Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198USA Univ Nebraska Omaha NE USA 68198 es Canc & Allied Dis, Omaha, NE 68198USA Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld 4072, Australia Univ Queensland St Lucia Qld Australia 4072 St Lucia, Qld 4072, Australia
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 6, volume: 8, anno: 2001,
pagine: 675 - 684
SICI:
0929-8673(200105)8:6<675:DORAOH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENT DECAPEPTIDE AGONIST; RECEPTOR-BINDING; CYCLOOXYGENASE PRODUCTS; C5A-MEDIATED RELEASE; MOLECULAR ADJUVANT; EFFECTOR REGION; IMMUNE-RESPONSE; BIASED AGONIST; COMPLEMENT; CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Sanderson, SD Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, 98680 Med Ctr,600 So 42nd St, Omaha, NE 68198 USA Univ Nebraska 98680 Med Ctr,600 So 42nd St Omaha NE USA 68198
Citazione:
S.M. Taylor et al., "Development of response-selective agonists of human C5a anaphylatoxin: Conformational, biological, and therapeutic considerations", CURR MED CH, 8(6), 2001, pp. 675-684

Abstract

Numerous studies on the relationship between the structure and function ofpeptide agonists derived from the biologically active, C-terminal region of human C5a anaphylatoxin have been reported over the past decade. These studies have been performed with the objective of parlaying this structure-function information into the design of peptide/peptidomimetic modulators of C5a receptor (C5aR)-mediated function. In this review, we describe a rational approach for the development of conformationally biased, decapeptide agonists of C5a and described how these stabilized and specific conformationalfeatures relate to the expression of specific C5a-like activities in vitroand in vivo. The therapeutic potential of such response-selective C5a agonists is discussed and underscored by the results of one such response-selective C5a agonist that was used in vivo as an effective molecular adjuvant capable of generating antigen-specific humoral and cellular immune responses. Finally, we describe the synthesis of a new generation of highly response-selective, conformationally biased C5a agonist and discuss the in vitro and in vivo biologic results that so indicate this biologic selectivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:42:32