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Titolo:
Peptidomics: The comprehensive analysis of peptides in complex biological mixtures
Autore:
Schulz-Knappe, P; Zucht, HD; Heine, C; Jurgens, M; Hess, R; Schrader, M;
Indirizzi:
BioVisioN GmbH & Co KG, D-30625 Hannover, Germany BioVisioN GmbH & Co KG Hannover Germany D-30625 -30625 Hannover, Germany
Titolo Testata:
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
fascicolo: 2, volume: 4, anno: 2001,
pagine: 207 - 217
SICI:
1386-2073(200104)4:2<207:PTCAOP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASS-SPECTROMETRY DATA; DESORPTION IONIZATION MALDI; IMMOBILIZED PH GRADIENTS; 2-DIMENSIONAL ELECTROPHORESIS; PROTEIN IDENTIFICATION; CURRENT STATE; HUMAN PLASMA; PROTEOMICS; ANGIOGENESIS; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Schulz-Knappe, P BioVisioN GmbH & Co KG, Feodor Lynen Str 5, D-30625 Hannover, Germany BioVisioN GmbH & Co KG Feodor Lynen Str 5 Hannover Germany D-30625
Citazione:
P. Schulz-Knappe et al., "Peptidomics: The comprehensive analysis of peptides in complex biological mixtures", COMB CHEM H, 4(2), 2001, pp. 207-217

Abstract

Progress in the sequencing of genomes has resulted in an increasing demandfor a functional analysis of gene products in order to understand the underlying physiology. Proteomics has established itself as a highly valuable technology for producing functionally related data in an unparalleled fashion, but is methodologically restricted to the analysis of proteins with higher molecular masses (>10 kDa). The development of a technology which. covers peptides with Pow molecular weight and small proteins (0.5 to 15 kDa) wasnecessary, since peptides, amongst them families of hormones, cytokines and growth factors, play a central role in many biological processes. To summarise the technologies used for this approach the term "peptidomics" is introduced. In this article, we present the rationale and first results of a novel, universal peptide display approach for the analysis and visualisationof peptides and small proteins from biological samples. Special attention is given to samples derived from extracellular fluids such as blood plasma and cerebrospinal fluid. Additionally, a high throughput identification procedure for the analysis of peptides in their native and processed molecularform is outlined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 03:00:03