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Titolo:
Identification and characterization of satellite III subfamilies to the acrocentric chromosomes
Autore:
Bandyopadhyay, R; McQuillan, C; Page, SL; Choo, KHA; Shaffer, LG;
Indirizzi:
Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Royal Childrens Hosp, Murdoch Childrens Res Inst, Murdoch, WA, Australia Royal Childrens Hosp Murdoch WA Australia s Inst, Murdoch, WA, Australia
Titolo Testata:
CHROMOSOME RESEARCH
fascicolo: 3, volume: 9, anno: 2001,
pagine: 223 - 233
SICI:
0967-3849(200104)9:3<223:IACOSI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIBOSOMAL-RNA GENES; DNA-SEQUENCES; ROBERTSONIAN TRANSLOCATIONS; HOMOLOGOUS CHROMOSOMES; REPETITIVE DNA; Y-CHROMOSOME; 14P+ VARIANT; EVOLUTION; HETEROCHROMATIN; LOCALIZATION;
Keywords:
acrocentric chromosome; chromosome evolution; fluorescence in-situ hybridization; repetitive DNA; satellite DNA; Robertsonian translocations;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Shaffer, LG Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USABaylor Coll Med Houston TX USA 77030 t, Houston, TX 77030 USA
Citazione:
R. Bandyopadhyay et al., "Identification and characterization of satellite III subfamilies to the acrocentric chromosomes", CHROMOS RES, 9(3), 2001, pp. 223-233

Abstract

The centromeres and the short arms of the five pairs of acrocentric chromosomes in humans are composed of tandemly ordered repetitive DNA. Previous studies have suggested that the exchanges between acrocentric chromosomes have resulted in concerted evolution of different DNA sequences in their short arms. The acrocentric chromosomes are clinically relevant since they are involved in Robertsonian translocation formation and non-disjunction resulting in aneuploidy. Here we have identified seven new satellite III repetitive DNA subfamilies, determined their nucleotide sequences and established their chromosomal distributions on the short arms of the acrocentric chromosomes. Knowledge of these related sequences may help to elucidate the molecular basis of Robertsonian translocation formation.

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Documento generato il 29/11/20 alle ore 16:13:34