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Titolo:
Protecting the myocardium from ischemic injury - A critical role for alpha(1)-adrenoreceptors?
Autore:
Salvi, S;
Indirizzi:
Univ Med, Southampton Gen Hosp, Dept Med, Southampton SO16 6YD, Hants, England Univ Med Southampton Hants England SO16 6YD pton SO16 6YD, Hants, England
Titolo Testata:
CHEST
fascicolo: 4, volume: 119, anno: 2001,
pagine: 1242 - 1249
SICI:
0012-3692(200104)119:4<1242:PTMFII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CARDIAC MYOCYTES; GLUCOSE-TRANSPORT; RECEPTOR SUBTYPES; BETA-BLOCKADE; NA+-H+; INFARCTION; STIMULATION; APOPTOSIS; ACTIVATION; HEART;
Keywords:
alpha(1)-adrenoreceptor; apoptosis; glucose; glucose transporter; ischemic preconditioning; Na+/H+ exchange; phosphofructokinase; protein kinase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Salvi, S Univ Med, Southampton Gen Hosp, Dept Med, Level D Ctr Block, Southampton SO16 6YD, Hants, England Univ Med Level D Ctr Block Southampton Hants England SO16 6YD and
Citazione:
S. Salvi, "Protecting the myocardium from ischemic injury - A critical role for alpha(1)-adrenoreceptors?", CHEST, 119(4), 2001, pp. 1242-1249

Abstract

Ischemic preconditioning (LPC) refers to the ability of short periods of ischemia to make the myocardium more resistant to a subsequent ischemic insult. It is the most powerful form of endogenous protection against myocardial infarction and has been demonstrated in all species evaluated to date. However, the cellular mechanisms that drive IPC remain poorly understood. This hypothesis describes an important role for alpha (1)-adrenoreceptors in mediating IBC and discusses the underlying mechanisms by which this is likely achieved. alpha (1)-Adrenoreceptors are present in the myocardium of all mammalian species, and several lines of evidence suggest that they play an important role in mediating IPC. During periods of myocardial hypoxia/ischemia, cardiomyocytes have to rely solely on anaerobic glycolysis for energy production; for this, the cells have to depend on increased glucose entry inside the cell as well as increased glycolysis. Stimulation of alpha (1)-adrenoreceptors increases glucose transport inside the cardiomyocytes by translocating glucose transporter (GLUT)-1 and GLUT-4 from the cytoplasm to theplasma membrane, enhances glycogenolysis by activating phosphorylase kinase, increases the rate of glycolysis by activating the enzyme phosphofructokinase, reduces intracellular acidity produced during excessive glycolysis by activating the Na+/H+ exchanger, and inhibits apoptosis by increasing thelevels of the antiapoptotic protein Bcl-2. Myocardial ischemia produces anincrease in the expression of alpha (1)-adrenoreceptors in cardiomyocytes,as well as increases the levels of its agonist norepinephrine by several fold. During ischemic states, upregulation of alpha (1)-adrenoreceptors and increase in norepinephrine release could be a powerful adaptive mechanism that drives IPC. An understanding into the role of alpha (1)-adrenoreceptorsin mediating IPC could not only point to newer treatments for limiting myocardial damage during myocardial infarction or heart surgery, but could also help in avoiding the use of alpha (1)-antagonists in patients with ischemic heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:07:27