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Titolo:
Impairment of vascular endothelial function and left ventricular filling -Association with the severity of apnea-induced hypoxemia during sleep
Autore:
Kraiczi, H; Caidahl, K; Samuelsson, A; Peker, Y; Hedner, J;
Indirizzi:
Sahlgrens Univ Hosp, Dept Pulm Med, Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden Dept Pulm Med, Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Clin Pharmacol, Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden lin Pharmacol, Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Clin Physiol, Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden Clin Physiol, Gothenburg, Sweden
Titolo Testata:
CHEST
fascicolo: 4, volume: 119, anno: 2001,
pagine: 1085 - 1091
SICI:
0012-3692(200104)119:4<1085:IOVEFA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTIMA-MEDIA THICKNESS; BLOOD-PRESSURE; EPISODIC HYPOXIA; BRACHIAL-ARTERY; ESSENTIAL-HYPERTENSION; MYOCARDIAL-INFARCTION; OBESE SUBJECTS; HEART-FAILURE; HYPERTROPHY; ECHOCARDIOGRAPHY;
Keywords:
brachial artery/ultrasonography; echocardiography; left ventricular function; left ventricular remodeling; obstructive sleep apnea; vascular endothelium/physiopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kraiczi, H Ctr Drug Dev Sci, 3900 Reservoir Rd NW,Med-Dent NE 412, Washington, DC 20007 USA Ctr Drug Dev Sci 3900 Reservoir Rd NW,Med-Dent NE 412 Washington DC USA 20007
Citazione:
H. Kraiczi et al., "Impairment of vascular endothelial function and left ventricular filling -Association with the severity of apnea-induced hypoxemia during sleep", CHEST, 119(4), 2001, pp. 1085-1091

Abstract

Study objectives: To investigate whether a dose-effect relationship existsbetween the severity of obstructive sleep apnea (OSA) and subclinical indicators of myocardial or vascular dysfunction. Design: Cross-sectional study using correlation analysis. Participants: Twenty subjects referred to our sleep laboratory for screening or therapy of OSA but without regular medication and without known cardiovascular disease. Measurements: Severity of OSA was quantified by polysomnography. Moreover,nocturnal excretion of norepinephrine was determined. Left ventricular (LV) myocardial function was assessed with Doppler echocardiography. Using ultrasonographic measurements, endothelium-dependent and endothelium-independent conduit artery dilation were measured as now-mediated and glyceryltrinitrate-induced changes in brachial artery diameter. Results: Worsening nocturnal hypoxemia, measured as nocturnal oxygen saturation nadir or percentage of sleep time spent in hypoxemia (< 90% hemoglobin oxygen saturation), predicted increased interventricular septum thickness(corrected for age and body mass index), prolonged isovolumetric relaxation time, decreased ratio between peak early and late mitral now velocities, as well as reduced endothelium-dependent dilatory capacity of the brachial artery tall relationships corrected for cofactor age and with p < 0.05) were observed, Associations between these cardiovascular function markers and nocturnal excretion of norepinephrine followed the same trend, but relations with interventricular septum thickness and flow-mediated artery dilation missed significance (p = 0.064 and p = 0.081, respectively). LV posterior wall thickness, measures of LV systolic function, early mitral now deceleration time, and endothelium-independent artery dilation were not significantly related to the degree of nocturnal hypoxemia or norepinephrine excretion. None of the correlations with apnea-hypopnea index were statistically significant,Conclusions: The severity of apnea-related hypoxemia is associated with a gradual deterioration of LV diastolic function as well as large-artery endothelial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/10/20 alle ore 00:40:41