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Titolo:
Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways
Autore:
Murphy, GA; Jillian, SA; Michaelson, D; Philips, MR; DEustachio, P; Rush, MG;
Indirizzi:
NYU, Sch Med, Dept Biochem, Taipei 10016, Taiwan NYU Taipei Taiwan 10016NYU, Sch Med, Dept Biochem, Taipei 10016, Taiwan NYU, Sch Med, Dept Cell Biol, Taipei 10016, Taiwan NYU Taipei Taiwan 10016 U, Sch Med, Dept Cell Biol, Taipei 10016, Taiwan NYU, Sch Med, Dept Med, Taipei 10016, Taiwan NYU Taipei Taiwan 10016NYU, Sch Med, Dept Med, Taipei 10016, Taiwan NYU, Sch Med, Kaplan Canc Ctr, Taipei 10016, Taiwan NYU Taipei Taiwan 10016 , Sch Med, Kaplan Canc Ctr, Taipei 10016, Taiwan
Titolo Testata:
CELL GROWTH & DIFFERENTIATION
fascicolo: 3, volume: 12, anno: 2001,
pagine: 157 - 167
SICI:
1044-9523(200103)12:3<157:SMBTCR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; GTP-BINDING PROTEIN; GDP-DISSOCIATION INHIBITOR; SACCHAROMYCES-CEREVISIAE GENE; CELL POLARITY; PC12 CELLS; MOLECULAR-CLONING; NEURITE OUTGROWTH; SODIUM-SALICYLATE; NEURONAL CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Rush, MG NYU, Sch Med, Dept Biochem, 550 1st Ave, Taipei 10016, Taiwan NYU550 1st Ave Taipei Taiwan 10016 st Ave, Taipei 10016, Taiwan
Citazione:
G.A. Murphy et al., "Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways", CELL GROWTH, 12(3), 2001, pp. 157-167

Abstract

The mammalian Rho family GTPases TC10 and Cdc42 share many properties. Activated forms of both proteins stimulate transcription mediated by nuclear factor kappaB, serum response factor, and the cyclin D1 promoter; activate c-Jun NH2-terminal kinase; cooperate with activated Raf to transform NIH-3T3cells; and, by a mechanism independent of all of these effects, induce filopodia formation. In contrast, previously reported differences between TC10and Cdc42 are not striking. We now present studies of TC10 and Cdc42 in cell culture that reveal clear functional differences: (a) wild-type TC10 localizes predominantly to the plasma membrane and less extensively to a perinuclear membranous compartment, whereas wild-type Cdc42 localizes predominantly to this compartment and less extensively to the plasma membrane; (b) expression of Rho guanine nucleotide dissociation inhibitor alpha results in a redistribution of wild-type Cdc42 to the cytosol but has no effect on theplasma membrane localization of wild-type TC10; (c) TC10 fails to rescue aSaccharomyces cerevisiae cdc42 mutation, unlike mammalian Cdc42; (d) dominant negative Cdc42, but not dominant negative TC10, inhibits neurite outgrowth in PC12 cells stimulated by nerve growth factor; and (e) activation of nuclear factor kappaB-dependent transcription by Cdc42, but not by TC10, isinhibited by sodium salicylate, These findings point to distinct pathways in which TC10 and Cdc42 may act and distinct modes of regulation of these proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:50:12