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Titolo:
The GGAs promote ARF-dependent recruitment of clathrin to the TGN
Autore:
Puertollano, R; Randazzo, PA; Presley, JF; Hartnell, LM; Bonifacino, JS;
Indirizzi:
NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 & Metab Branch, NIH, Bethesda, MD 20892 USA NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CELL
fascicolo: 1, volume: 105, anno: 2001,
pagine: 93 - 102
SICI:
0092-8674(20010406)105:1<93:TGPARO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADP-RIBOSYLATION FACTOR; GTPASE-ACTIVATING PROTEIN; AP-3 ADAPTER COMPLEX; GOLGI MEMBRANES; GAMMA-ADAPTIN; MEDIATED ENDOCYTOSIS; SYNTHETIC LIPOSOMES; BINDING PROTEIN; TRANS-GOLGI; FACTOR-I;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bonifacino, JS NICHHD, Cell Biol & Metab Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 , NIH, Bethesda, MD 20892 USA
Citazione:
R. Puertollano et al., "The GGAs promote ARF-dependent recruitment of clathrin to the TGN", CELL, 105(1), 2001, pp. 93-102

Abstract

The GGAs constitute a family of modular adaptor-related proteins that bindADP-ribosylation factors (ARFs) and localize to the trans-Golgi network (TGN) via their GAT domains. Here, we show that binding of the GAT domain stabilizes membrane-bound ARF1 . GTP due to interference with the action of GTPase-activating proteins. We also show that the hinge and ear domains of the GGAs interact with clathrin in vitro, and that the GGAs promote recruitment of clathrin to liposomes in vitro and to TGN membranes in vivo. These observations suggest that the GGAs could function to link clathrin to membrane-bound ARF GTP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:38:49