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Titolo:
The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women
Autore:
Cheng, YW; Chiou, HL; Sheu, GT; Hsieh, LL; Chen, JT; Chen, CY; Su, JM; Lee, H;
Indirizzi:
Chung Shan Med & Dent Coll, Inst Med, Taichung 40203, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan 40203 Taichung 40203, Taiwan Chung Shan Med & Dent Coll, Inst Toxicol, Taichung, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan st Toxicol, Taichung, Taiwan Chung Shan Med & Dent Coll, Dept Med Technol, Taichung, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan ed Technol, Taichung, Taiwan Chung Shan Med & Dent Coll, Dept Thorac Surg, Taichung, Taiwan Chung Shan Med & Dent Coll Taichung Taiwan horac Surg, Taichung, Taiwan Taichung Vet Gen Hosp, Dept Pathol, Taichung, Taiwan Taichung Vet Gen Hosp Taichung Taiwan sp, Dept Pathol, Taichung, Taiwan Taichung Vet Gen Hosp, Dept Thorac Surg, Taichung, Taiwan Taichung Vet GenHosp Taichung Taiwan ept Thorac Surg, Taichung, Taiwan Chang Gung Univ, Dept Publ Hlth, Tao Yuan, Taiwan Chang Gung Univ Tao Yuan Taiwan Univ, Dept Publ Hlth, Tao Yuan, Taiwan
Titolo Testata:
CANCER RESEARCH
fascicolo: 7, volume: 61, anno: 2001,
pagine: 2799 - 2803
SICI:
0008-5472(20010401)61:7<2799:TAOHP1>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53 PROTEIN ACCUMULATION; BRONCHOPULMONARY CARCINOMAS; DNA; TYPE-16; NEOPLASIA; PROGNOSIS; GENE; HPV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, H Chung Shan Med & Dent Coll, Inst Med, 110,Sec 1,Chien Kuo N Rd, Taichung 40203, Taiwan Chung Shan Med & Dent Coll 110,Sec 1,Chien Kuo N Rd Taichung Taiwan 40203
Citazione:
Y.W. Cheng et al., "The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women", CANCER RES, 61(7), 2001, pp. 2799-2803

Abstract

Lung cancer is the leading cause of cancer death in Taiwanese women since 1982, High lung cancer mortality ratio of male:female in Taiwan (2:1) was observed, although less than 10% of female lung cancer patients are smokers. Until now, the etiological factor remains unknown. We hypothesize that high-risk human papillomavirus (HPV) 16/18 may be associated with lung cancer development based on high prevalence of p53 negative immunostainings in female lung tumors compared with that of male lung tumors. In this study, 141 lung cancer patients and 60 noncancer control subjects were enrolled to examine whether HPV 16/18 DNA existed in lung tumor and normal tissues by nested PCR and in situ hybridization (ISH), respectively. The concordant detection of HPV 16 and 18 DNA between nested PCR and ISH method was 73 and 85.5%, respectively. Our data showed that 77 (54.6%) of 141 lung tumors had HPV 16/18 DNA compared with 16 (26.7%; P = 0.0005) of 60 noncancer control subjects. In addition, ISH data showed that HPV 16/18 DNA was uniformly locatedin lung tumor cells, but not in the adjacent nontumor cells. When study subjects were stratified by gender, age, and smoking status, nonsmoking female lung cancer patients who were older than 60 years old had significantly high prevalence of HPV 16/18 infection. The odds ratio of HPV 16/18 infection of nonsmoking female lung cancer patients is much higher at 10.12 (95% confidence interval, 3.88-26.38) compared with 1.98 (95% confidence interval,0.84-4.76) of nonsmoking male lung cancer patients. This result strongly suggests that HPV infection is associated with lung cancer development of nonsmoking female lung cancer patients. The high prevalence of HPV 16/18 infection may explain to a certain extent why Taiwanese women nonsmokers had a higher lung cancer mortality rate.

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Documento generato il 25/01/21 alle ore 15:10:48