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Titolo:
Schizophrenia and the frontal lobes - Post-mortem stereological study of tissue volume
Autore:
Highley, JR; Walker, MA; Esiri, MM; McDonald, B; Harrison, PJ; Crow, TJ;
Indirizzi:
Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX ept Psychiat, Oxford OX3 7JX, England Radcliffe Infirm, Dept Clin Neurol, Schizophrenia Res Grp, Oxford OX2 6HE,England Radcliffe Infirm Oxford England OX2 6HE Res Grp, Oxford OX2 6HE,England
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 178, anno: 2001,
pagine: 337 - 343
SICI:
0007-1250(200104)178:<337:SATFL->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; PREFRONTAL CORTEX; CEREBRAL ASYMMETRY; CINGULATE GYRUS; CORPUS-CALLOSUM; GRAY-MATTER; POSTMORTEM; ABNORMALITIES; SIZE; GENDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Crow, TJ Univ Oxford, Warneford Hosp, Dept Psychiat, Neurosci Bldg, OxfordOX3 7JX,England Univ Oxford Neurosci Bldg Oxford England OX3 7JX OX3 7JX,England
Citazione:
J.R. Highley et al., "Schizophrenia and the frontal lobes - Post-mortem stereological study of tissue volume", BR J PSYCHI, 178, 2001, pp. 337-343

Abstract

Background It has been suggested that there is frontal lobe involvement inschizophrenia. and that it may be lateralised and gender-specific. Aims To clarify the structure of the frontal robes in schizophrenia in a postmortem series. Method The volume of white matter and cortical components of the frontal lobes was measured in brains of controls and patients with schizophrenia using planimetry and the Cavalieri principle. The components measured were: superior frontal gyrus, middle frontal gyrus, a composite of inferior frontalgyrus and orbite-frontal cortex. as well as total frontal lobe cortex and white matter. In addition. the anterior cingulate gyrus was measured. Results No diagnosis,gender, diagnosis x side, diagnosis x gender or diagnosis x gender x side interactions were observed in the volume of any of thecomponents, the grey matter as a whole or the white matter. No evidence for volumetric inter-group differences was found for the anterior cingulate gyrus. Conclusions Such structural abnormalities as are present in the frontal robes are more subtle than straightforward alterations in tissue volume; theymay include changes in shape and the pattern of gyral folding. Declaration of interest This work was supported by The Medical Research Council and The Wellcome Trust.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:20:59