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Titolo:
Chronic benzodiazepine use in general practice patients with depression: an evaluation of controlled treatment and taper-off - Report on behalf of the Dutch Chronic Benzodiazepine Working Group
Autore:
Zitman, FG; Couvee, JE;
Indirizzi:
LUMC St Radboud, Dept Psychiat, BIP, NL-2300 RC Leiden, Netherlands LUMC St Radboud Leiden Netherlands NL-2300 RC 300 RC Leiden, Netherlands SmithKline Beecham Farma BV, Dept Med, Rijswijk, Netherlands SmithKline Beecham Farma BV Rijswijk Netherlands Rijswijk, Netherlands
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 178, anno: 2001,
pagine: 317 - 324
SICI:
0007-1250(200104)178:<317:CBUIGP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENCE; WITHDRAWAL; DISCONTINUATION; DIAZEPAM; PLACEBO; TRIALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Zitman, FG LUMC St Radboud, Dept Psychiat, BIP, POB 9600, NL-2300 RC Leiden, Netherlands LUMC St Radboud POB 9600 Leiden Netherlands NL-2300 RC erlands
Citazione:
F.G. Zitman e J.E. Couvee, "Chronic benzodiazepine use in general practice patients with depression: an evaluation of controlled treatment and taper-off - Report on behalf of the Dutch Chronic Benzodiazepine Working Group", BR J PSYCHI, 178, 2001, pp. 317-324

Abstract

Background Many patients with depression take benzodiazepine drugs long term despite the absence of continuing therapeutic value. Aims To evaluate a treatment programme involving gradual discontinuation with or without simultaneous selective serotonin reuptake inhibitor (SSRI) prescribing and to determine the long-term outcome after benzodiazepine withdrawal. Method Patients went through three phases - change to an equivalent dose of diazepam; subsequent randomisation to either 20 mg of paroxetine or placebo: and gradual reduction of diazepam in depression-free patients - with a follow-up after 2 or 3 years. Results A total of 230 patients were recruited and 75% in the paroxetine group and 61% in the placebo group were successfully treated after 6 weeks (P=0.067). After 2 or 3 years 13% of patients were still benzodiazepine free: 26% of those who had successfully tapered off benzodiazepine and 6% of the total group. Conclusions Transfer to diazepam followed by gradual withdrawal is an effective way of discontinuing chronic benzodiazepine use. The addition of SSRItreatment is of limited value. Declaration of interest J.E.C. is employed by Smith Kline Beecham. Smith Kline Beecham Farma by, The Netherlands, funded the study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:18:42