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Titolo:
Neuroprotective effects of GDNF against 6-OHDA in young and aged rats
Autore:
Fox, CM; Gash, DM; Smoot, MK; Cass, WA;
Indirizzi:
Univ Kentucky, Chandler Med Ctr MN 225, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Neurobiol, Lexington, KY 40536 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 896, anno: 2001,
pagine: 56 - 63
SICI:
0006-8993(20010330)896:1-2<56:NEOGA6>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGROSTRIATAL DOPAMINERGIC SYSTEM; HUMAN SUBSTANTIA-NIGRA; NEUROTROPHIC FACTOR; STRIATAL DOPAMINE; PARKINSONS-DISEASE; MESSENGER-RNA; IN-VIVO; FISCHER-344 RATS; UPTAKE SITES; NEURONS;
Keywords:
glial cell line-derived neurotrophic factor (GDNF); dopamine; striatum; substantia nigra; tyrosine hydroxylase; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Cass, WA Univ Kentucky, Chandler Med Ctr MN 225, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 ol, Lexington, KY 40536 USA
Citazione:
C.M. Fox et al., "Neuroprotective effects of GDNF against 6-OHDA in young and aged rats", BRAIN RES, 896(1-2), 2001, pp. 56-63

Abstract

In young adult rats, glial cell line-derived neurotrophic factor (GDNF) can completely protect against 6-hydroxydopamine-induced loss of nigral dopamine neurons when administered 6 h prior to the 6-hydroxydopamine. The present study was undertaken to determine if GDNF would provide similar protective effects: in aged rats. Male, Fischer 344 X Brown Norway hybrid rats of 3, 18 and 24 months of age were given an intranigral injection of GDNF or vehicle followed 6 h later with an intranigral injection of 6-hydroxydopamine. Nigral dopamine neuron cell survival, and striatal and nigral dopamine and DOPAC levels, were evaluated 2 weeks after the lesions. In vehicle treated animals cell survival on the lesioned side ranged from 15 to 27%. GDNF promoted significant cell survival in the nigra of all three age groups; however, the percent survival was lowest in the 24-month-old animals (85% at 3 months, 75% at 18 months, 56% at 24 months). Similarly, dopamine levels in the striatum and substantia nigra on the lesioned side remained significantly greater in the GDNF treated animals compared to the vehicle treated animals. As with the cell survival experiment, the protective effects of GDNF on dopamine levels were less in the 24-month-old animals. GDNF pretreatment also protected against 6-hydroxydopamine-induced reductions in striatal DOPAC levels in all age groups. Overall, these results indicate that GDNF can protect nigrostriatal dopamine neurons against the effects of 6-hydroxydopamine in aged as well as young adult rats. However, the extent of protectionis less in the aged (24-month-old) animals. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:54:54