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Titolo:
Myocardial insulin-mediated glucose uptake and left ventricular geometry
Autore:
Sundstrom, J; Lind, L; Valind, S; Holmang, A; Bjorntorp, P; Andren, B; Waldenstrom, A; Lithell, H;
Indirizzi:
Sahlgrens Univ Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Wallenberg Lab, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Univ Umea Hosp, Dept Med, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185 Hosp, Dept Med, S-90185 Umea, Sweden Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci Geriatr, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden & Caring Sci Geriatr, Uppsala, Sweden Univ Uppsala Hosp, Dept Med Sci, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden la Hosp, Dept Med Sci, Uppsala, Sweden Univ Uppsala Hosp, PET Ctr, Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden Uppsala Hosp, PET Ctr, Uppsala, Sweden
Titolo Testata:
BLOOD PRESSURE
fascicolo: 1, volume: 10, anno: 2001,
pagine: 27 - 32
SICI:
0803-7051(2001)10:1<27:MIGUAL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; ESSENTIAL-HYPERTENSION; CARDIAC-HYPERTROPHY; BLOOD-PRESSURE; HEART; RESISTANCE; MASS; HYPERINSULINEMIA; DISEASE; POPULATION;
Keywords:
glucose; glucose clamp technique; insulin; left ventricular hypertrophy; metabolism; ventricular remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Sundstrom, J Dept Public Hlth & Caring Sci Geriatr, SE-75125 Uppsala, Sweden Dept Public Hlth & Caring Sci Geriatr Uppsala Sweden SE-75125
Citazione:
J. Sundstrom et al., "Myocardial insulin-mediated glucose uptake and left ventricular geometry", BLOOD PRESS, 10(1), 2001, pp. 27-32

Abstract

Whole-body insulin sensitivity has been shown to be impaired in subjects with increased left ventricular relative wall thickness (RWT) and in hypertensive subjects with left ventricular hypertrophy, but the relation between myocardial insulin sensitivity and RWT or left ventricular mass index (LVMI) in normotension is not known. We measured myocardial and skeletal muscle glucose uptake with [F-18]fluorodeoxyglucose and positron emission tomography during hyperinsulinemic euglycemic clamp in nine men with wide ranges ofechocardiographic RWT and LVMI. The subjects: were male, 72-74 years old, normotensive and free from medication or history of heart disease. RWT correlated inversely with skeletal muscle glucose uptake (r = -0.69, p = 0.04),borderline significantly directly with myocardial glucose uptake (r = 0.62, p = 0.07), and directly with the ratio between myocardial and skeletal muscle glucose uptake (r = 0.77, p = 0.02) during hyperinsulinemic euglycemicclamp. LVMI was not related to insulin-mediated myocardial or skeletal muscle glucose uptake or the ratio between myocardial and skeletal muscle glucose uptake. In conclusion, RWT was inversely related to insulin sensitivityin skeletal muscle and borderline significantly directly related to insulin sensitivity in the myocardium in healthy normotensive elderly men, whereas LVMI was not related to myocardial or skeletal muscle insulin sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:29:12