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Titolo:
A high-fat meal does not activate blood coagulation factor VII in minipigs
Autore:
Olsen, AK; Larsen, LF; Bladbjerg, EM; Hansen, AK; Jespersen, J; Marckmann, P;
Indirizzi:
Ribe Cty Hosp, Dept Clin Biochem, DK-6700 Esbjerg, Denmark Ribe Cty Hosp Esbjerg Denmark DK-6700 Biochem, DK-6700 Esbjerg, Denmark Univ So Denmark, Dept Thrombosis Res, Odense, Denmark Univ So Denmark Odense Denmark rk, Dept Thrombosis Res, Odense, Denmark Royal Vet & Agr Univ, Res Dept Human Nutr, Frederiksberg, Denmark Royal Vet & Agr Univ Frederiksberg Denmark Nutr, Frederiksberg, Denmark Royal Vet & Agr Univ, Dept Pharmacol & Pathobiol, Frederiksberg, Denmark Royal Vet & Agr Univ Frederiksberg Denmark biol, Frederiksberg, Denmark
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 2, volume: 12, anno: 2001,
pagine: 117 - 122
SICI:
0957-5235(200103)12:2<117:AHMDNA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE-RICH LIPOPROTEINS; ISCHEMIC-HEART-DISEASE; FACTOR-XII; POSTPRANDIAL ACTIVATION; PLASMA-CONCENTRATIONS; SPECIES-SPECIFICITY; HEMOSTATIC FACTORS; CLOTTING FACTORS; ATHEROSCLEROSIS; DEFICIENCY;
Keywords:
animal model; diet; triglycerides; thrombosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Olsen, AK Ribe Cty Hosp, Dept Clin Biochem, Ostergade 80, DK-6700 Esbjerg,Denmark Ribe Cty Hosp Ostergade 80 Esbjerg Denmark DK-6700 erg, Denmark
Citazione:
A.K. Olsen et al., "A high-fat meal does not activate blood coagulation factor VII in minipigs", BL COAG FIB, 12(2), 2001, pp. 117-122

Abstract

It is a matter of debate whether postprandial activation of blood coagulation factor VII (FVII) is associated with an increased risk of thrombosis. To clarify this question, an animal model in which consequences of dietary FVII activation can be studied in a more detailed way would be an important tool. We studied postprandial FVII activation in seven non-fasting Gottingen minipigs, Intralipid (4 g/kg) was administered through a gastric tube in two fractions at 9.00 a.m. (one-third of total dose) and 10.30 a.m. (two-thirds of total dose). Blood samples were drawn 0.5 h before (baseline) and 2, 3, 3.5, 4, 5, and bh after the first fat load Triglycerides, activated FVII (FVIIa), FVII coagulant activity (FVIIc), FVII amidolytic activity (FVIIam) and prothrombin fragment 1 + 2 (F1 + 2) were analysed in plasma samples. Median plasma triglycerides were significantly raised from 0.67 mmol/l (baseline) to 2.56 mmol/l 5 h postprandially (P < 0.001). There were no significant changes in FVIIa (9.6 U/l at baseline), FVIIam (142% at baseline) and F1 + 2 (0.13 nmol/l at baseline). FVIIc decreased from 141% at baseline to 114% 6 h postprandially (P<0.001). As a high-fat meal does not seem to activate blood coagulation FVII in minipigs, the pig is apparently not a relevant model for the study of dietary FVII activation and thrombin generation. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 28/09/20 alle ore 01:52:58