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Titolo:
Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis
Autore:
Suehisa, E; Nomura, T; Kawasaki, T; Kanakura, Y;
Indirizzi:
Osaka Univ Hosp, Cent Lab Clin Invest, Suita, Osaka 5650871, Japan Osaka Univ Hosp Suita Osaka Japan 5650871 st, Suita, Osaka 5650871, Japan Osaka Univ, Sch Med, Dept Surg 2, Suita, Osaka 565, Japan Osaka Univ Suita Osaka Japan 565 ed, Dept Surg 2, Suita, Osaka 565, Japan
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 2, volume: 12, anno: 2001,
pagine: 95 - 99
SICI:
0957-5235(200103)12:2<95:FONCI(>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; HEALTHY POPULATION; VENOUS THROMBOSIS; FUNCTIONAL ASSAY; PREVALENCE; THROMBOEMBOLISM; OUTPATIENTS; RESISTANCE; ABSENCE;
Keywords:
frequency; antithrombin III; protein C; protein S; deficiency; deep vein thrombosis; Japanese;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Suehisa, E Osaka Univ Hosp, Cent Lab Clin Invest, 2-15 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ Hosp 2-15 Yamadaoka Suita Osaka Japan 5650871 Japan
Citazione:
E. Suehisa et al., "Frequency of natural coagulation inhibitor (antithrombin III, protein C and protein S) deficiencies in Japanese patients with spontaneous deep vein thrombosis", BL COAG FIB, 12(2), 2001, pp. 95-99

Abstract

One hundred and thirteen consecutive Japanese patients with deep venous thrombosis (DVT) were studied for the incidences of antithrombin III (AT-III), protein C (PC) and protein S (PS) deficiencies, and the results were compared with those of normal subjects. Ten of the 392 normal Japanese subjectswere found with PS deficiency (n = 8, 2.02%) or PC deficiency (n = 2, 0.5%). PS deficiencies comprised type I (1/8, 12.5%), type II (4/8, 50%), and type III (3/8, 37.5%). All PC deficiencies were type I. Among patients with DVT, 32 (28.3%) were deficient in AT-III, PC and PS. These patients consisted of two AT-III deficiency (1.77%), nine PC deficiency (7.96%), 20 PS deficiency (17.7%), and one combined deficiency of PC and PS (0.88%). Both of the patients with AT-III deficiency were classified as type II, all those with PC deficiency as type I, and those with PS deficiency as type I in 25% (5/20), type II in 55% (11/20) and type In in 20% (4/20). The frequency of PC and PS deficiencies in patients with DVT were 15.6 and 7.38 times the control population frequency, respectively, and this difference was statistically significant (P<0.05). These data suggest that the Japanese population has a high frequency of PC and PS deficiencies. We recommend that PS activity should be measured for screening of thrombosis since type II deficiency accounted for approximately 50% of PS deficiency cases in both patients and the normal group in the Japanese. <(c)> 2001 Lippincott Williams & Wilkins.

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Documento generato il 29/09/20 alle ore 08:42:22