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Titolo:
The overactive bladder in children: a potential future indication for tolterodine
Autore:
Hjalmas, K; Hellstrom, AL; Mogren, K; Lackgren, G; Stenberg, A;
Indirizzi:
Univ Uppsala, Akad Childrens Hosp, S-75105 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75105 ldrens Hosp, S-75105 Uppsala, Sweden Sahlgrens Univ Hosp, Queen Silvias Childrens Hosp, Urotherapy Unit, SE-41685 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41685 -41685 Gothenburg, Sweden
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 6, volume: 87, anno: 2001,
pagine: 569 - 574
SICI:
1464-4096(200104)87:6<569:TOBICA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYBUTYNIN CHLORIDE; INTRAVESICAL OXYBUTYNIN; DETRUSOR HYPERREFLEXIA; ANTIMUSCARINIC AGENT; NEUROGENIC BLADDER; CLINICAL EFFICACY; SAFETY; INSTABILITY; PLACEBO; SERUM;
Keywords:
tolterodine; antimuscarinic agents; children; overactive bladder; dose-finding study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hjalmas, K Sahlgrens Univ Hosp, Queen Silvias Childrens Hosp, Urotherapy Unit, SE-41685 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41685 enburg, Sweden
Citazione:
K. Hjalmas et al., "The overactive bladder in children: a potential future indication for tolterodine", BJU INT, 87(6), 2001, pp. 569-574

Abstract

Objective To determine the safety, efficacy and pharmacokinetics of tolterodine in children with an overactive bladder. Patients and methods Thirty-three children (20 boys and 13 girls, aged 5-10 years) with an overactive bladder and symptoms of urgency, frequency and/or urge incontinence were enrolled in an open, dose-escalation study. Patients were treated with oral tolterodine 0.5 mg (n=11), 1 mg (n=10) or 2 mg (n=12)twice daily for 14 days. The primary safety endpoint was the change inresidual urinary volume, as determined by ultrasonography. In addition, voiding diary variables (frequency and incontinence episodes) and pharmacokinetics were evaluated. Other safety endpoints included laboratory variables,electrocardiogram recordings and reported adverse events. Results There were no safety concerns in terms of the change in residual urinary volume for any of the three dosage groups; Values were comparable with baseline after 2 weeks of treatment for all three dosages. Adverse events were reported by 20 patients (six on 0.5 mg, five on 1 mg, and nine on 2 mg). Most adverse events were not considered to be drug-related: of the 13 possibly related events, 10 occurred in those taking 2 mg, Headache was themost commonly reported adverse event. No serious adverse events were reported and there were no general safety concerns. There was an improvement in voiding diary variables in all treatment groups after 2 weeks of treatment,although the efficacy was greatest in those taking 1 mg and 2 mg, Pharmacokinetic findings were consistent with dose linearity over the range consistent 0.5-2 mg. Conclusion The results support the use of 1 mg twice daily as the optimal dose of tolterodine for treating children aged 5-10 years with an overactive bladder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:39:20