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Titolo:
Urinary transforming growth factor-alpha in individuals exposed to arsenicin drinking water in Bangladesh
Autore:
Do, T; Gambelunghe, A; Ahsan, H; Graziano, J; Perrin, M; Slavkovich, V; Parvez, F; Milton, AH; Brandt-Rauf, P;
Indirizzi:
Columbia Univ, Mailman Sch Publ Hlth, Div Environm Hlth Sci, New York, NY 10032 USA Columbia Univ New York NY USA 10032 ronm Hlth Sci, New York, NY 10032 USA NGO Forum, Dhaka, Bangladesh NGO Forum Dhaka BangladeshNGO Forum, Dhaka, Bangladesh
Titolo Testata:
BIOMARKERS
fascicolo: 2, volume: 6, anno: 2001,
pagine: 127 - 132
SICI:
1354-750X(200103/04)6:2<127:UTGFII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-ALPHA; TRANSGENIC MICE; CANCER-PATIENTS; SERUM LEVELS; OVEREXPRESSION; NEOPLASIA; BREAST;
Keywords:
transforming growth factor-alpha; arsenic; drinking water; skin lesions; biomarker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Brandt-Rauf, P Columbia Univ, Mailman Sch Publ Hlth, Div Environm Hlth Sci, 60 Haven Ave,B-1, New York, NY 10032 USA Columbia Univ 60 Haven Ave,B-1 New York NY USA 10032 32 USA
Citazione:
T. Do et al., "Urinary transforming growth factor-alpha in individuals exposed to arsenicin drinking water in Bangladesh", BIOMARKERS, 6(2), 2001, pp. 127-132

Abstract

Recent evidence suggests that the development of skin lesions from arsenicexposure may be mediated by increases in the expression of various growth factors, including transforming growth factor-alpha (TGF alpha). To investigate this association in humans, levels of total urinary arsenic and urinary TGF alpha were determined in 41 individuals with and without arsenic-associated skin lesions from Bangladesh who have chronic exposure to arsenic intheir drinking water. After adjusting for age and sex, total urinary arsenic was found to be correlated with urinary TGF alpha (R-2 = 0. 37; p < 0.0001), particularly in those individuals with arsenic-associated skin lesions(R-2 = 0.70; p < 0.0001). Stratification of the cohort into quartiles based on urinary TGF alpha levels demonstrated a trend of increasing odds ratios for the presence of arsenic-associated skin lesions with increasing urinary TGF alpha, although this was not significant (p = 0.15). These results suggest that urinary TGF alpha may be a useful biomarker for the epidermal effects of arsenic exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:43:06