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Titolo:
Lysophosphatidylcholine derived from deer antler extract suppresses hyphaltransition in Candida albicans through MAP kinase pathway
Autore:
Min, J; Lee, YJ; Kim, YA; Park, HS; Han, SY; Jhon, GJ; Choi, W;
Indirizzi:
Ewha Womans Univ, Dept Biol Sci, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 Sci, Seoul 120750, South Korea Ewha Womans Univ, Dept Chem, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 hem, Seoul 120750, South Korea Ewha Womans Univ, Ctr Cell Signaling Res, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 Res, Seoul 120750, South Korea Ewha Womans Univ, Div Mol Life Sci, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 Sci, Seoul 120750, South Korea
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
fascicolo: 1-2, volume: 1531, anno: 2001,
pagine: 77 - 89
SICI:
1388-1981(20010330)1531:1-2<77:LDFDAE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; HUMAN T-LYMPHOCYTES; VIRULENCE; MONOACETYLDIGLYCERIDES; GROWTH; MORPHOGENESIS; EXPRESSION; FUNGUS; CELLS; TUP1;
Keywords:
2-lysophosphatidylcholine; deer antler extract; hyphal transition; mitogen-activated protein kinase pathway; Candida albicans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, W Ewha Womans Univ, Dept Biol Sci, Seoul 120750, South Korea Ewha Womans Univ Seoul South Korea 120750 ul 120750, South Korea
Citazione:
J. Min et al., "Lysophosphatidylcholine derived from deer antler extract suppresses hyphaltransition in Candida albicans through MAP kinase pathway", BBA-MOL C B, 1531(1-2), 2001, pp. 77-89

Abstract

A family of 2-lysophosphatidylcholines (lyso-PCs) was isolated from deer antler extract, guided exclusively by hyphal transition inhibitory activity in Candida albicans. Structural determination of the isolated lyso-PCs by spectroscopic methods, including infrared spectroscopy, H-1 nuclear magneticresonance (NMR), C-13 NMR, 2D correlation spectroscopy NMR, fast atom bombardment mass spectrometry and tandem mass spectrometry, confirmed that the natural products were composed of at least four different lyso-PCs varying in fatty acid moiety at the sn-l position of the glycerol backbone. The major lyso-PCs were confirmed as l-stearoyl-, l-oleoyl-, l-linoleoyl- and l-palmitoyl-2-lyso-sn-glycero-3-phosphatcholines. Lyse-PC specifically suppressed the morphogenic transition from yeast to hyphae in C. albicans, without affecting the growth of either yeast or hyphae. Lyse-PC exerted hyphal transition that suppressed activity in the broad spectrum of the Candida species, such as C. albicans, Candida krusei, Candida guilliermondii and Candida parapsilosis. Northern analysis indicated that the suppression was mediatedthrough the mitogen-activated protein kinase pathway. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:29:41