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Titolo:
Bone changes in early rheumatoid arthritis
Autore:
Green, MJ; Deodhar, AA;
Indirizzi:
Univ Leeds, Rheumatol Res Unit, Leeds LS1 3EX, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS1 3EX S1 3EX, W Yorkshire, England Oregon Hlth Sci Univ, Div Arthrit & Rheumat Dis L329A, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 L329A, Portland, OR 97201 USA
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 105 - 123
SICI:
1521-6942(200103)15:1<105:BCIERA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE REPLACEMENT THERAPY; X-RAY ABSORPTIOMETRY; MINERAL DENSITY; T-CELLS; OSTEOCLAST DIFFERENTIATION; OSTEOPROTEGERIN LIGAND; JOINT DESTRUCTION; MASS; OSTEOPOROSIS; HAND;
Keywords:
rheumatoid arthritis; osteoporosis; hand bone densitometry; osteoprotegerin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Deodhar, AA Univ Leeds, Rheumatol Res Unit, Leeds LS1 3EX, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS1 3EX rkshire, England
Citazione:
M.J. Green e A.A. Deodhar, "Bone changes in early rheumatoid arthritis", BEST PR R C, 15(1), 2001, pp. 105-123

Abstract

Bone disease in rheumatoid arthritis affects the peri-articular and axial skeleton and is a major cause of disability. Recent studies have shown thatpro-inflammatory cytokines stimulate the expression of osteoprotegerin ligand, a transmembrane protein of the tumour necrosis factor ligand superfamily, on synoviocytes and activated T cells. Osteoprotegerin ligand stimulates osteoclast formation and activation, membrane-bound and soluble osteoprotegerin ligand leading to osteoporosis as well as erosions. Bone densitometry using dual energy X-ray absorptiometry is an objective and precise methodfor monitoring this bone disease. Bone loss is more rapid in patients withearly rheumatoid arthritis and correlates well with measures of inflammation and function. Data are emerging that monitoring bone loss of the hands in early rheumatoid arthritis could be an outcome measure and a prognostic indicator of future functional disability. Suppressing inflammation effectively and the use of bone active agents can reduce the rate of loss. In animal models, osteoprotegerin - a decoy receptor of osteoprotegerin ligand - blocks osteoporosis and erosions without affecting inflammation. The use of new biological agents could in future effectively prevent and treat rheumatoid bone disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:01:33