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Titolo:
Is early rheumatoid arthritis the same disease process as late rheumatoid arthritis?
Autore:
Tak, PP;
Indirizzi:
Acad Med Ctr, Div Clin Immunol & Rheumatol, NL-1100 DE Amsterdam, Netherlands Acad Med Ctr Amsterdam Netherlands NL-1100 DE DE Amsterdam, Netherlands
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 17 - 26
SICI:
1521-6942(200103)15:1<17:IERATS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; CARTILAGE PANNUS JUNCTION; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; MONOCLONAL-ANTIBODY TREATMENT; SYNOVIAL TISSUE; ADJUVANT ARTHRITIS; ADHESION MOLECULES; RECEPTOR ANTAGONIST; P53 OVEREXPRESSION;
Keywords:
rheumatoid arthritis; disease stages; synovial tissue; inflammation; pathogenesis; treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Tak, PP Acad Med Ctr, Div Clin Immunol & Rheumatol, POB 22700, NL-1100 DE Amsterdam, Netherlands Acad Med Ctr POB 22700 Amsterdam Netherlands NL-1100 DE therlands
Citazione:
P.P. Tak, "Is early rheumatoid arthritis the same disease process as late rheumatoid arthritis?", BEST PR R C, 15(1), 2001, pp. 17-26

Abstract

Thoughts on treatment for the early control of synovitis have stimulated research on pathobiological events at the site of inflammation in patients with early rheumatoid arthritis. Several studies have thus been conducted toexamine synovial biopsy samples at various stages of the disease. The mostimportant conclusion from these studies is that all features of chronic synovial inflammation can be observed in so-called early rheumatoid arthritis. This suggests that no arguments exist for the effect of therapeutic intervention on synovitis varying in different phases of rheumatoid arthritis. In end-stage rheumatoid arthritis, factors that are secondary to the diseasemay contribute to the perpetuation of synovial inflammation. Mutations in key regulatory genes could play a role in the autonomous progression of thedisease. In addition, it is conceivable that the release of bone and cartilage fragments might elicit an inflammatory response in patients with destructive rheumatoid arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:17:05