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Titolo:
Chemotherapy resistance in acute myeloid leukaemia
Autore:
Sonneveld, P; List, AF;
Indirizzi:
Univ Rotterdam Hosp, Dept Hematol, NL-3000 CA Rotterdam, Netherlands Univ Rotterdam Hosp Rotterdam Netherlands NL-3000 CA terdam, Netherlands Univ Arizona, Coll Med, Blood & Marrow Transplant Program, Arizona Canc Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 , Arizona Canc Ctr, Tucson, AZ 85724 USA
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 211 - 233
SICI:
1521-6926(200103)14:1<211:CRIAML>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-GLYCOPROTEIN EXPRESSION; GLUTATHIONE-S-TRANSFERASE; ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOCYTIC-LEUKEMIA; MDR1 GENE-EXPRESSION; TUMOR-CELL LINES; MEDIATED MULTIDRUG RESISTANCE; CLINICAL DRUG-RESISTANCE; SOUTHWEST-ONCOLOGY-GROUP; NON-HODGKINS-LYMPHOMA;
Keywords:
acute myeloid leukaemia; multidrug resistance; MDR; MRP; LRP; P-glycoprotein; PSC 833; cyclosporin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
185
Recensione:
Indirizzi per estratti:
Indirizzo: Sonneveld, P Univ Rotterdam Hosp, Dept Hematol, Rm L407,POB 2040, NL-3000 CA Rotterdam,Netherlands Univ Rotterdam Hosp Rm L407,POB 2040 Rotterdam Netherlands NL-3000 CA
Citazione:
P. Sonneveld e A.F. List, "Chemotherapy resistance in acute myeloid leukaemia", BEST P R C, 14(1), 2001, pp. 211-233

Abstract

The development of refractory disease in acute myeloid leukaemia (AML) is frequently associated with the expression of one or several multidrug resistance (MDR) genes. MDRI, MRPI and LRP have been identified as important adverse prognostic factors in AML. Recently it has become possible to reverse clinical multidrug resistance by blocking P-glycoprotein-mediated drug efflux. The potential relevance of MDR and new approaches to treat refractory disease, are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:06:10