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Titolo:
Developmental approaches in immunological control of acute myelogenous leukaemia
Autore:
Torelli, GF; Orsini, E; Guarini, A; Kell, J; Foa, R;
Indirizzi:
Univ La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, I-00161 Rome,Italy Univ La Sapienza Rome Italy I-00161 llulari & Ematol, I-00161 Rome,Italy Univ Wales, Coll Med, Dept Haematol, Cardiff CF14 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF14 4XN Cardiff CF14 4XN, S Glam, Wales
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 189 - 209
SICI:
1521-6926(200103)14:1<189:DAIICO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; MONOCLONAL-ANTIBODY M195; CYTOTOXIC T-LYMPHOCYTES; GRAFT-VERSUS-LEUKEMIA; MINOR HISTOCOMPATIBILITY ANTIGENS; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOBLASTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; PERIPHERAL-BLOOD LYMPHOCYTES;
Keywords:
AML; immunotherapy; immunological control; donor lymphocytes; cytokines; gene therapy; dendritic cells; antibody directed therapy; CD33; calicheamicin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
141
Recensione:
Indirizzi per estratti:
Indirizzo: Foa, R Univ La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Via Benevento6, I-00161 Rome, Italy Univ La Sapienza Via Benevento 6 Rome Italy I-00161 61 Rome, Italy
Citazione:
G.F. Torelli et al., "Developmental approaches in immunological control of acute myelogenous leukaemia", BEST P R C, 14(1), 2001, pp. 189-209

Abstract

After many years of hope and disillusionment, the possibility of utilizingimmune-mediated approaches to control neoplastic clones has become a reality in various haematological malignancies. This is largely a consequence ofthe continuous advances in knowledge and the progressive development of more refined technologies that have led to a better understanding of the biology of the malignant cells and of the host immune system, to a more precisedefinition of disease entities and to the design of innovative therapeuticprogrammes. In this chapter, we will review different immunological strategies that have reached clinical practice in patients with acute myelogenousleukaemia (AML), the focus of this volume, and discuss preclinical developments that may in the near future translate into the design of new immunotherapeutic protocols for the management of AML. Treatment of AML with antibody directed therapy will also be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:21:52